{"product_id":"vetoquinol-usa-upcard-ca1-toresemide-oral-solution-for-dogs","title":"Vetoquinol USA - UpCard CA1 (toresemide) Oral Solution for Dogs","description":"\u003ch2\u003e\u003cimg width=\"700\" alt=\"RX MAP\" class=\"img-responsive\" src=\"https:\/\/hordypaw.shop\/cdn\/shop\/files\/rx-map.webp\" data-original=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\" data-files=\"rx-map.jpg\" loading=\"lazy\"\u003e\u003c\/h2\u003e\n\u003ch2\u003eSupports Pulmonary Edema Management in Dogs\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eUpCard®-CA1 is a once-daily oral torsemide solution formulated specifically for dogs with congestive heart failure caused by myxomatous mitral valve disease (MMVD). As a loop diuretic, it helps manage pulmonary edema by promoting controlled fluid removal. Designed for use alongside pimobendan, spironolactone, and an ACE inhibitor, it offers high oral bioavailability and is conditionally approved by the FDA for long-term management under veterinary supervision.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOnce-Daily Dosing\u003c\/strong\u003e: Administered orally once daily, supporting convenient long-term management of stable CHF cases.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh Bioavailability\u003c\/strong\u003e: Demonstrates approximately 96% bioavailability, supporting consistent systemic exposure following oral administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTargeted Diuretic Action\u003c\/strong\u003e: Inhibits the Na+\/2Cl-\/K+ transporter in the loop of Henle to promote effective fluid removal.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProven Field Response\u003c\/strong\u003e: Achieved a 96% treatment success rate at Day 84 in evaluated stable MMVD cases.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlexible Administration\u003c\/strong\u003e: May be given with or without food, offering adaptable dosing options for individual patients.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eIngredients\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eActive Ingredients\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eTorsemide (2 mg\/ml; 0.2% w\/v)\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eInactive Ingredients\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eTromethamine, hydroxyethyl cellulose, saccharin sodium, propylene glycol.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eHow to Use\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eRecommended-Dosage Chart\u003c\/strong\u003e\u003c\/h4\u003e\n\u003ctable style=\"width: 36.5108%; height: 55px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"168\" style=\"width: 33.1209%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eBody Weight Basis\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"148\" style=\"width: 29.1608%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eTorsemide Dose\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"188\" style=\"width: 37.0811%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eOral Solution Volume\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"168\" style=\"width: 33.1209%; height: 35.5966px;\"\u003e\n\u003cp\u003ePer lb body weight\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"148\" style=\"width: 29.1608%; height: 35.5966px;\"\u003e\n\u003cp\u003e0.05–0.2 mg\/lb\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"188\" style=\"width: 37.0811%; height: 35.5966px;\"\u003e\n\u003cp\u003e0.025–0.1 ml\/lb\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"168\" style=\"width: 33.1209%; height: 35.5966px;\"\u003e\n\u003cp\u003ePer kg body weight\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"148\" style=\"width: 29.1608%; height: 35.5966px;\"\u003e\n\u003cp\u003e0.11–0.44 mg\/kg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"188\" style=\"width: 37.0811%; height: 35.5966px;\"\u003e\n\u003cp\u003e0.055–0.22 ml\/kg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eMaximum Dose:\u003c\/strong\u003e Do not exceed 0.2 mg\/lb (0.44 mg\/kg) per day, equivalent to 0.1 ml\/lb (0.22 ml\/kg).\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Administration Instructions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOnce Daily Dosing: \u003c\/strong\u003eGive orally once a day within the recommended dose range based on body weight.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcurrent Therapy: \u003c\/strong\u003eUse with pimobendan, spironolactone, and an ACE inhibitor for managing CHF when indicated\u003cstrong\u003e. \u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStable Patients Only:\u003c\/strong\u003e Intended for clinically stable dogs with MMVD, not for emergency pulmonary edema cases.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDose Adjustments: \u003c\/strong\u003eAdjust dosage in 25% increments under veterinary supervision within the recommended limits.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonitoring Required: \u003c\/strong\u003eCheck hydration, BUN, creatinine, and electrolytes before and after making therapy adjustments.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFood Flexibility: \u003c\/strong\u003eCan be given with or without food, based on veterinary guidance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Required: \u003c\/strong\u003eFederal law limits this medication to use by or on the order of a licensed veterinarian.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eAdditional Information\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003ePrecautions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNot Emergency Use\u003c\/strong\u003e: Not indicated for dogs requiring immediate injectable diuretic therapy for an acute crisis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePre-Treatment Assessment\u003c\/strong\u003e: Correct dehydration and electrolyte abnormalities prior to initiating therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRenal Monitoring\u003c\/strong\u003e: Regularly monitor BUN, creatinine, and electrolytes, especially during early treatment stages.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Interactions\u003c\/strong\u003e: Use caution with NSAIDs, aminoglycosides, cephalosporins, corticosteroids, and cardiac glycosides.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLimited Evaluations\u003c\/strong\u003e: Safety not evaluated in congenital heart disease, diabetes, breeding, pregnant, or lactating dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSulfonamide Sensitivity\u003c\/strong\u003e: May induce allergic reactions in dogs with known sulfonamide allergies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003ePossible Side Effects\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIncreased Urination: \u003c\/strong\u003ePolyuria and polydipsia often occur during torsemide treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRenal Changes: \u003c\/strong\u003eThere may be increased BUN, serum creatinine, and a higher risk of kidney problems.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eElectrolyte Imbalance: \u003c\/strong\u003eHypokalemia, hypochloremia, hypercalcemia, and hypomagnesemia can happen during treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Upset: \u003c\/strong\u003eSome dogs may experience vomiting, diarrhea, and a reduced appetite.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLethargy Signs: \u003c\/strong\u003eA decrease in activity or signs of lethargy may be seen in some dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWorsening CHF: \u003c\/strong\u003eClinical studies have reported cough, dyspnea, pulmonary edema, and cardiac arrest.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTemperature Limit\u003c\/strong\u003e: Store at or below 30°C (86°F).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTemperature Excursions\u003c\/strong\u003e: Excursions permitted between 4°C and 40°C (39°F and 104°F).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiscard Timeline\u003c\/strong\u003e: Discard bottle 90 days after first opening.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSecure Storage\u003c\/strong\u003e: Keep in a secure location out of reach of pets and children.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eShipping \u0026amp; Return\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, priority, and international delivery; see our \u003ca href=\"\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE. \u003c\/strong\u003e \u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eQ1: What is UpCard®-CA1 used for in dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e UpCard®-CA1 is prescribed to manage pulmonary edema in dogs with congestive heart failure from myxomatous mitral valve disease (MMVD). It is for stable patients and should be given with pimobendan, spironolactone, and an ACE inhibitor under the supervision of a veterinarian.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ2: How is UpCard®-CA1 dosed for dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e UpCard®-CA1 is administered orally once daily at 0.05–0.2 mg per pound (0.11–0.44 mg\/kg) of body weight. The maximum recommended dose is 0.2 mg\/lb (0.44 mg\/kg) per day. Dose adjustments should be made in 25% increments under veterinary guidance.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ3: Can UpCard®-CA1 be given with food?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e UpCard®-CA1 can be given with or without food. Feeding has been shown to raise overall drug exposure (AUC) by about 24%, but it does not significantly change the peak concentration. Your veterinarian will decide the best way to give it to your dog.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ4: What monitoring is required while using UpCard®-CA1?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Dogs receiving UpCard®-CA1 require regular monitoring of hydration status, blood urea nitrogen (BUN), serum creatinine, and electrolyte levels. Assessments should be performed before starting therapy, within 24 and 48 hours after initiation or dose adjustments, and periodically thereafter as directed by a veterinarian.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ5: What are the most common side effects of UpCard®-CA1?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e The most commonly reported adverse reactions include increased urination, increased thirst, elevated BUN and creatinine, and electrolyte disturbances such as hypokalemia. Gastrointestinal signs like vomiting or diarrhea and lethargy have also been reported. Renal insufficiency may occur and requires veterinary monitoring.\u003c\/p\u003e\n\u003ch2\u003eHigh Authority Medical Resources:\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/animaldrugsatfda.fda.gov\/adafda\/app\/search\/public\/document\/download?objectId=347f19d7-63ef-4d67-a00d-d97a8ef946c7\"\u003eFDA Veterinary Drug Listings - UpCard CA1\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=3d5cc810-e8c8-4b55-a7fd-0a9999cb6c37\" title=\"Dailymed - upcard-ca1 torsemide- torsemide solution\" aria-label=\"Visit a webpage about Dailymed - upcard-ca1 torsemide- torsemide solution\"\u003eDailyMed - Torsemide Oral Solution Info\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.merckvetmanual.com\/pharmacology\/systemic-pharmacotherapeutics-of-the-cardiovascular-system\/diuretics-for-use-in-animals?autoredirectid=21718\" title=\"Diuretics for use in animals - pharmacology - merck veterinary manual\" aria-label=\"Visit a webpage about Diuretics for use in animals - pharmacology - merck veterinary manual\"\u003eMerck Veterinary Manual - Diuretic Therapy\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Vetoquinol","offers":[{"title":"32-mL","offer_id":44611225616545,"sku":"456795","price":31.99,"currency_code":"USD","in_stock":true},{"title":"96-mL","offer_id":44611225649313,"sku":"456796","price":84.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/vetoquinol-usa-upcard-ca1-toresemide-oral-solution-for-dogs-pet-192.jpg?v=1778151726","url":"https:\/\/hordypaw.shop\/products\/vetoquinol-usa-upcard-ca1-toresemide-oral-solution-for-dogs","provider":"HardyPaw","version":"1.0","type":"link"}