{"product_id":"immiticide-melarsomine-dihydrochloride-canine-heartworm-treatment-50mg-2ml-5-vials","title":"Immiticide Injection - Heartworm Treatment For Dogs 50mg, 2mL (5 vials)","description":"\u003ch1\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cimg loading=\"lazy\" data-files=\"rx-map.jpg\" data-original=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\" src=\"https:\/\/hordypaw.shop\/cdn\/shop\/files\/rx-map.webp\" alt=\"Rx Map\" border=\"0\"\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/h1\u003e\n\u003ch2\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eProven adult heartworm treatment for Class 1-3 dogs\u003c\/b\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eProduct Description\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eImmiticide Injection - Heartworm Treatment for Dogs 50mg, 2mL (5 vials) delivers melarsomine dihydrochloride, the only FDA-approved adulticide for stabilized Class 1-3 canine \u003ca href=\"\/collections\/dog-medications\" title=\"Dog medications: allergy, antibiotics, heartworm \u0026amp; more! | hardypaw\" aria-label=\"Dog medications: allergy, antibiotics, heartworm \u0026amp; more! | hardypaw\"\u003eheartworm disease\u003c\/a\u003e. This prescription treatment kills immature and adult heartworms in the pulmonary arteries and heart, helping reduce clinical signs, limit further organ damage, and support safer long-term recovery under strict veterinary supervision.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eBenefits\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul type=\"disc\" style=\"margin-top: 0cm;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eTargeted Adulticide Action:\u003c\/b\u003e Kills immature and mature adult Dirofilaria immitis heartworms in infected dogs.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eClass 1-3 Indication:\u003c\/b\u003e Labeled for stabilized Class 1, 2, and 3 heartworm disease cases.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eEvidence-Backed Efficacy:\u003c\/b\u003e Clinical trials show high worm-reduction and antigen-conversion rates after treatment.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eVeterinarian-Administered Protocol:\u003c\/b\u003e Deep intramuscular dosing performed only by licensed veterinarians for safety.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eConvenient Multi-Vial Pack:\u003c\/b\u003e Five 50 mg vials support complete treatment courses for appropriately sized dogs.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eIngredients\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eActive Ingredient:\u003c\/b\u003e Melarsomine Dihydrochloride 50 mg.\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eInactive Ingredients:\u003c\/b\u003e Sodium Citrate, Glycine, and Water for Injection.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eHow to Use\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003e\u003cspan style=\"font-style: normal;\"\u003eDosage \u0026amp; Administration Instructions\u003c\/span\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul type=\"disc\" style=\"margin-top: 0cm;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eDeep IM Injection Only:\u003c\/b\u003e Administer by deep intramuscular injection in the lumbar (epaxial) muscles L3-L5. Do not inject intravenously or in any other muscle group.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eStandard Dose Rate:\u003c\/b\u003e Dose at 2.5 mg\/kg (0.1 mL\/kg) per injection, accurately calculated from the dog’s weight using the dosing table.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eClass 1-2 Regimen:\u003c\/b\u003e Give 2.5 mg\/kg intramuscularly twice, 24 hours apart; a second two-dose series may be considered four months later based on response and condition.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eClass 3 Alternate Regimen:\u003c\/b\u003e Stabilize first, then give one 2.5 mg\/kg injection; about one month later, administer 2.5 mg\/kg twice, 24 hours apart.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eReconstitution and Use:\u003c\/b\u003e Reconstitute each 50 mg vial only with the supplied 2 mL sterile diluent; use immediately or within 24 hours if refrigerated and protected from light.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eAdditional Information\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003e\u003cspan style=\"font-style: normal;\"\u003ePrecautions\u003c\/span\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/h4\u003e\n\u003cul type=\"disc\" style=\"margin-top: 0cm;\"\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eDisease Class Limitation:\u003c\/b\u003e Contraindicated in dogs with very severe (Class 4) heartworm disease and caval syndrome.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eLow Safety Margin:\u003c\/b\u003e Immiticide has a low margin of safety; overdosing or incorrect administration can cause severe toxicity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eRoute and Site Restrictions:\u003c\/b\u003e Must be given only as deep intramuscular injections in lumbar epaxial muscles; avoid superficial injection or leakage.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eThromboembolism Risk:\u003c\/b\u003e All treated dogs’ risk post-treatment pulmonary thromboembolism; strict exercise restriction and close monitoring are essential after injections.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"color: rgb(0, 0, 0);\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eUse in Breeding Dogs:\u003c\/b\u003e Safety has not been determined in breeding animals or pregnant or lactating bitches; use only if benefits outweigh risks in veterinary judgment.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eShipping \u0026amp; Returns\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp style=\"margin: 12.0pt 0cm 12.0pt 0cm;\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eWe offer ground, express, priority, and international delivery; see our \u003ca aria-label=\"Shipping policy | hardypaw\" title=\"Shipping policy | hardypaw\" style=\"color: rgb(0, 0, 0);\" href=\"\/pages\/shipping-policy\"\u003e\u003cspan style=\"color: rgb(0, 0, 255);\"\u003eshipping policy\u003c\/span\u003e\u003c\/a\u003e for details.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"margin: 12.0pt 0cm 12.0pt 0cm;\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFor return instructions or product concerns, please refer to our detailed \u003cspan style=\"color: rgb(0, 0, 255);\"\u003e\u003ca aria-label=\"Refund policy\" title=\"Refund policy\" style=\"color: rgb(0, 0, 255);\" href=\"\/policies\/refund-policy\"\u003erefund policy\u003c\/a\u003e\u003c\/span\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"margin: 12.0pt 0cm 12.0pt 0cm;\" class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"mso-ascii-font-family: Aptos; mso-fareast-font-family: Aptos; mso-hansi-font-family: Aptos; mso-bidi-font-family: Aptos;\"\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"margin: 12.0pt 0cm 12.0pt 0cm;\" class=\"MsoNormal\"\u003e \u003c\/p\u003e\n\u003ch2\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eFrequently Asked Questions\u003c\/b\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eQ1: What is Immiticide Injection - Heartworm Treatment for Dogs 50mg, 2mL (5 vials) used for?\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAns: Immiticide Injection is a prescription treatment used to eliminate immature and adult heartworms in dogs diagnosed with stabilized Class 1, 2, or 3 heartworm disease. It is the only FDA-approved melarsomine adulticide, administered exclusively by veterinarians via deep intramuscular injection.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eQ2: How does this heartworm treatment work inside the dog’s body?\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAns: The medication contains melarsomine dihydrochloride, an organic arsenical compound that targets adult Dirofilaria immitis worms lodged in the heart and pulmonary arteries. As worms die, the body gradually clears them, which helps reduce disease progression but requires strict rest to limit complications.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eQ3: Which dogs are candidates for treatment with this injectable heartworm medication?\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAns: This product is indicated for dogs with confirmed Class 1, 2, or stabilized Class 3 heartworm disease. Veterinarians perform staging using clinical signs, imaging, and lab work, then determine whether the dog is stable enough to undergo adulticide therapy and which dosing protocol is safest.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eQ4: How many injections are typically required for a complete treatment course?\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAns: Most dogs receive either a two-dose series or a three-dose alternate regimen. For many Class 1 and 2 dogs, two injections are administered 24 hours apart, sometimes followed by another two-dose series months later. Stabilized Class 3 dogs usually receive the three-dose protocol.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eQ5: Why is strict exercise restriction so necessary after adult heartworm treatment?\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAns: When heartworms die, fragments can lodge in pulmonary vessels, causing thromboembolism. Limiting activity reduces strain on the heart and lungs during this fragile period. Veterinarians typically recommend cage rest or minimal movement for several weeks after injections to enhance safety and improve outcomes.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eQ6: What common side effects might occur following injections with this medication?\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAns: Dogs frequently experience localized injection-site reactions, such as pain, swelling, tenderness, or stiffness, along with systemic signs, including coughing, lethargy, reduced appetite, fever, or abnormal lung sounds. Most reactions resolve with time and supportive care, though rare severe events can occur.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eQ7: Can dogs with very advanced heartworm disease receive this injectable treatment?\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAns: Immiticide is contraindicated in dogs with very severe Class 4 heartworm disease, especially those with caval syndrome. These patients typically require alternate interventions such as surgical worm extraction and intensive supportive care instead of standard melarsomine adulticide treatment protocols.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eQ8: Who is allowed to mix and inject this heartworm medication?\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAns: Only licensed veterinarians, or trained staff under direct veterinary supervision, should reconstitute the sterile powder and administer deep lumbar intramuscular injections. Accurate dosing, careful handling, and immediate access to medical support are essential because of the medication’s low safety margin and potential adverse reactions.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eQ9: How is the correct dose determined for each dog?\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAns: The veterinarian weighs the dog precisely, then calculates the total dose using 2.5 mg\/kg, equivalent to 0.1 mL\/kg of reconstituted solution. A dosing table helps verify that the chosen volume matches the dog’s body weight before each injection is administered.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cb\u003eQ10: How should the vials be stored and handled before and after reconstitution?\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAns: Unreconstituted vials are stored upright at controlled room temperature. Immediately before use, the powder is aseptically reconstituted with the supplied sterile water. The solution should be used promptly, within 24 hours if refrigerated and protected from light, and then discarded.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Boehringer Ingelheim","offers":[{"title":"Default Title","offer_id":43600421781665,"sku":"144999-BI","price":395.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/immiticide-injection-heartworm-treatment-for-dogs-50mg-2ml-5-vials-563.png?v=1778127033","url":"https:\/\/hordypaw.shop\/products\/immiticide-melarsomine-dihydrochloride-canine-heartworm-treatment-50mg-2ml-5-vials","provider":"HardyPaw","version":"1.0","type":"link"}