{"product_id":"doxycycline-oral-suspension-25mg-ml-60-ml","title":"Doxirobe (doxycycline hyclate) Gel","description":"\u003ch1\u003e\u003cimg src=\"https:\/\/hordypaw.shop\/cdn\/shop\/files\/rx-map.webp\" class=\"img-responsive\" alt=\"RX MAP\" width=\"700\" data-original=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\" data-files=\"rx-map.jpg\" loading=\"lazy\"\u003e\u003c\/h1\u003e\n\u003ch2\u003e\u003cstrong\u003eVeterinary Periodontal Treatment Gel for Canines\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eDOXIROBE Gel is a formulation of doxycycline hyclate that veterinarians use for managing and treating periodontal disease in dogs. It is administered directly into periodontal pockets that are 4 mm deep or more, offering continuous local antimicrobial effects against bacteria linked to periodontal disease. The biodegradable polymer sets in position and slowly releases doxycycline, enhancing attachment levels and decreasing pocket depth within a time frame of 2 to 4 weeks.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLocalized Antibiotic Action\u003c\/strong\u003e: Delivers doxycycline directly into periodontal pockets for targeted antimicrobial effect against gram-negative anaerobic bacteria.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSustained Drug Release:\u003c\/strong\u003e The polymer delivery system hardens within the pocket and slowly releases doxycycline for ongoing local efficacy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiodegradable Formula:\u003c\/strong\u003e Creates a solid, flexible matrix that does not need to be extracted during subsequent visits.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Proven:\u003c\/strong\u003e Clinical studies demonstrated increases in attachment levels, a decrease in pocket depth, and enhanced gingival health.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLow Systemic Exposure\u003c\/strong\u003e: Detectable plasma concentrations remained below levels associated with systemic activity or toxicity.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eIngredients\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eComposition Table\u003c\/strong\u003e\u003c\/h4\u003e\n\u003ctable style=\"width: 31.8802%; height: 48px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 73.2621%; height: 35.5966px;\" width=\"412\"\u003e\n\u003cp\u003e\u003cstrong\u003eIngredient\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 26.4608%; height: 35.5966px;\" width=\"167\"\u003e\n\u003cp\u003e\u003cstrong\u003eQuantity\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 73.2621%; height: 35.5966px;\" width=\"412\"\u003e\n\u003cp\u003eDoxycycline hyclate is equivalent to doxycycline anhydrous\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 26.4608%; height: 35.5966px;\" width=\"167\"\u003e\n\u003cp\u003e42.5 mg per 0.5 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003e\u003cstrong\u003eOther Ingredients\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eN-methyl-2-pyrrolidone, poly DL lactide\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eHow to Use\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eRecommended-Usage Chart\u003c\/strong\u003e\u003c\/h4\u003e\n\u003ctable style=\"width: 35.9765%; height: 94px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 35.461%; height: 35.5966px;\" width=\"200\"\u003e\n\u003cp\u003e\u003cstrong\u003eCondition\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 64.0818%; height: 35.5966px;\" width=\"403\"\u003e\n\u003cp\u003e\u003cstrong\u003eApplication Guidance\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 55.1989px;\"\u003e\n\u003ctd style=\"width: 35.461%; height: 55.1989px;\" width=\"200\"\u003e\n\u003cp\u003ePeriodontal pockets ≥ 4 mm\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 64.0818%; height: 55.1989px;\" width=\"403\"\u003e\n\u003cp\u003eFill each affected pocket with mixed gel to the gingival margin.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 35.461%; height: 35.5966px;\" width=\"200\"\u003e\n\u003cp\u003eMultiple affected teeth\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 64.0818%; height: 35.5966px;\" width=\"403\"\u003e\n\u003cp\u003eUse as many units as required to fill all diseased pockets.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Administration Instructions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVeterinary Prescription Only\u003c\/strong\u003e: This medication is limited by federal law to administration by or under the direction of a licensed veterinarian.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePre-Clean Teeth\u003c\/strong\u003e: Perform scaling and cleaning prior to gel application to ensure proper periodontal pocket preparation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMix Thoroughly\u003c\/strong\u003e: Exchange materials between Syringe A and Syringe B approximately 100 times for a consistent mixture.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSubgingival Placement\u003c\/strong\u003e: Insert a blunt cannula 1 to 2 mm below the gingival margin before expressing gel.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFill Pockets Fully\u003c\/strong\u003e: Express gel into periodontal pockets 4 mm or deeper up to the gingival margin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllow Hardening\u003c\/strong\u003e: Permit the polymer to solidify for 30 to 60 seconds before pressing it into the pocket.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eAdditional Information\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003ePrecautions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eYoung Dogs Warning\u003c\/strong\u003e: Do not use in dogs under one year due to the risk of permanent tooth discoloration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy Restriction\u003c\/strong\u003e: Avoid use in pregnant bitches as safety during pregnancy has not been established.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBreeding Dogs\u003c\/strong\u003e: The safety of this product has not been assessed in breeding dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSuspend Brushing:\u003c\/strong\u003e Inform clients to refrain from brushing the treated teeth for about two weeks following the treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNot For Certain Lesions:\u003c\/strong\u003e This product is not suitable for oronasal fistulas, periapical abscesses, or teeth that are severely compromised.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003ePossible Side Effects\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLow Systemic Exposure:\u003c\/strong\u003e Measurable plasma levels of doxycycline were lower than those known to cause systemic toxicity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLocalized Reaction Potential:\u003c\/strong\u003e Similar to periodontal procedures, localized reactions at the application site might occur after subgingival delivery.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoom Temperature Storage\u003c\/strong\u003e: Store at controlled room temperature between 15° and 30°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstituted Product Use\u003c\/strong\u003e: Store mixed product at 15° to 25°C and use within three days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdditional Mixing Required\u003c\/strong\u003e: Perform ten additional syringe exchanges if stored after initial mixing.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eShipping \u0026amp; Return\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe offer ground, express, priority, and international delivery; see our \u003ca href=\"\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eFrequently Asked Questions\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eQ1: What is DOXIROBE Gel used for in dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e DOXIROBE Gel is indicated for the treatment and control of periodontal disease in dogs. It is applied into periodontal pockets 4 mm or deeper, where it releases doxycycline locally to target bacteria associated with periodontal disease and improve gingival health within 2 to 4 weeks.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ2: How does DOXIROBE Gel work inside the periodontal pocket?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e After being mixed, the gel is applied below the gum line, solidifying upon contact with the gingival crevicular fluid. This forms a biodegradable structure that gradually releases doxycycline into the periodontal pocket, providing targeted antimicrobial action against the gram-negative anaerobic bacteria linked to periodontal disease.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ3: Does DOXIROBE Gel cause systemic antibiotic effects?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e In clinical studies, the peak plasma levels of doxycycline were observed six hours post-administration and remained beneath the thresholds linked to systemic effects or toxicity. Plasma samples showed no doxycycline presence at 24 hours or beyond, suggesting limited systemic exposure.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ4: Does DOXIROBE Gel need to be removed after treatment?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Gel removal is not mandatory. The polymer delivery system solidifies within the periodontal pocket and is biodegradable. As it gradually breaks down, it continues releasing doxycycline locally, eliminating the need for a follow-up visit to remove the material.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ5: Can DOXIROBE Gel be used in all dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e DOXIROBE Gel should not be used in dogs less than one year of age due to the risk of permanent tooth discoloration associated with tetracyclines. It is also not recommended for pregnant dogs, and safety has not been evaluated in breeding dogs.\u003c\/p\u003e","brand":"Zoetis","offers":[{"title":"1 syringe","offer_id":44416798261409,"sku":"169108-1","price":115.99,"currency_code":"USD","in_stock":true},{"title":"3 syringes","offer_id":44416798294177,"sku":"169109","price":299.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/doxirobe-doxycycline-hyclate-gel-pet-medicine-151.png?v=1778517094","url":"https:\/\/hordypaw.shop\/products\/doxycycline-oral-suspension-25mg-ml-60-ml","provider":"HardyPaw","version":"1.0","type":"link"}