{"product_id":"pcp-012zoe-5193","title":"Sileo (dexmedetomidine oromucosal) Oromucosal Gel for Dogs","description":"\u003ch2\u003e\u003cstrong\u003eCalm Relief for Dogs With Noise Aversion\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eSileo is a prescription oromucosal gel formulated to help dogs manage fear and anxiety caused by loud noises such as fireworks. It contains dexmedetomidine, an alpha 2 adrenoceptor agonist that calms dogs without heavy sedation. Applied between the cheek and gum, it allows dogs to remain awake, responsive, and comfortable during stressful noise events.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTargeted calming:\u003c\/strong\u003e Helps reduce fear and anxiety behaviors linked to loud noise exposure in dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNon-sedating action:\u003c\/strong\u003e Keeps dogs calm yet alert, allowing normal interaction during noise events.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast absorption:\u003c\/strong\u003e Oromucosal delivery allows effective absorption without relying on digestion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvent-based dosing:\u003c\/strong\u003e Designed for use before or during predictable noise-triggering situations.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFDA-approved use:\u003c\/strong\u003e Approved specifically for canine noise aversion under veterinary supervision.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eVariants\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e1 x 3 mL syringe\u003c\/li\u003e\n\u003cli\u003e3 x 3 mL syringes\u003c\/li\u003e\n\u003cli\u003e5 x 3 mL syringes\u003c\/li\u003e\n\u003cli\u003e10 x 3 mL syringes\u003c\/li\u003e\n\u003cli\u003e20 x 3 mL syringes\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eIngredients\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eActive Ingredients\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eDexmedetomidine as dexmedetomidine hydrochloride.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eInactive Ingredients\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eInactive ingredients are not publicly specified by the manufacturer.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eHow to Use\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eRecommended-Dosage Chart\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eEach “dot” equals \u003cstrong\u003e0.25 mL\u003c\/strong\u003e as measured using the dosing ring on the SILEO syringe.\u003cbr\u003eSource: SILEO FDA Approved Label, Zoetis Inc.\u003c\/p\u003e\n\u003ctable style=\"width: 33.1269%; height: 381px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e\u003cstrong\u003eBody Weight (lb)\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e\u003cstrong\u003eNumber of Dots\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e\u003cstrong\u003eTotal Volume (mL)\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e4.4 to 12.1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e1 dot\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e0.25 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e12.2 to 26.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e2 dots\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e0.50 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e26.6 to 44.0\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e3 dots\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e0.75 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e44.1 to 63.9\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e4 dots\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e1.00 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e64.0 to 86.0\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e5 dots\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e1.25 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e86.1 to 110.2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e6 dots\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e1.50 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e110.3 to 137.8\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e7 dots\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e1.75 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e137.9 to 166.4\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e8 dots\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e2.00 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e166.5 to 196.2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e9 dots\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e2.25 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd style=\"width: 32.5809%; height: 35.5966px;\" width=\"136\"\u003e\n\u003cp\u003e196.3 to 220.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.9609%; height: 35.5966px;\" width=\"129\"\u003e\n\u003cp\u003e10 dots\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 35.821%; height: 35.5966px;\" width=\"149\"\u003e\n\u003cp\u003e2.50 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Administration Instructions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOromucosal Placement:\u003c\/strong\u003e Administer between cheek and gum to ensure absorption through oral mucosa and avoid swallowing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDo Not Swallow:\u003c\/strong\u003e If swallowed, effectiveness may decrease and re-dosing must wait at least two hours.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTiming Before Noise:\u003c\/strong\u003e Give first dose 30 to 60 minutes before expected noise or at first anxiety signs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTwo Hour Interval:\u003c\/strong\u003e Maintain minimum two hours between doses and do not exceed five doses per event.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDivide Large Doses:\u003c\/strong\u003e Split doses exceeding six dots evenly between both sides of the mouth.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUse Dosing Syringe:\u003c\/strong\u003e Always administer using supplied syringe to prevent incorrect dosing or overdose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdult Administration:\u003c\/strong\u003e An adult should administer while wearing impermeable disposable gloves for safety.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Only:\u003c\/strong\u003e Use only under direction of a licensed veterinarian as required by federal law.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eDisclaimer: \u003c\/em\u003e\u003c\/strong\u003e\u003cem\u003eThis dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eAdditional Information\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003ePrecautions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealth conditions:\u003c\/strong\u003e Not labeled for dogs with severe cardiovascular, respiratory, liver, or kidney disease.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTemperature sensitivity:\u003c\/strong\u003e Sensitive dogs may experience reduced body temperature and should be monitored closely.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug interactions:\u003c\/strong\u003e Concurrent use with other central nervous system depressants may increase effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAge limitations:\u003c\/strong\u003e Safety has not been evaluated in dogs younger than sixteen weeks of age.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReproductive safety:\u003c\/strong\u003e Use in breeding, pregnant, or lactating dogs has not been evaluated.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003ePossible Side Effects\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMild sedation:\u003c\/strong\u003e Some dogs may appear drowsy or mildly sedated following labeled use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal signs:\u003c\/strong\u003e Vomiting or gastrointestinal upset has been reported in a small number of cases.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePale gums:\u003c\/strong\u003e Temporary pale mucous membranes may be observed and typically resolve without treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUrinary changes:\u003c\/strong\u003e Urinary incontinence or inappropriate urination has been reported infrequently.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTemperature range:\u003c\/strong\u003e Store at controlled room temperature between 20°C and 25°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOriginal packaging:\u003c\/strong\u003e Syringes should be kept in the original carton to protect product stability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOpened syringe:\u003c\/strong\u003e Contents should be used within four weeks after initial opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eShipping \u0026amp; Return\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, priority, and international delivery; see our \u003ca href=\"\/en-ro\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-ro\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE. \u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eFrequently Asked Questions\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eQ1: What is Sileo used for in dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Sileo is an FDA-approved prescription medication indicated for treating noise aversion in dogs. It is labeled to help reduce fear and anxiety behaviors triggered by loud noises such as fireworks, while allowing dogs to remain calm, responsive, and functional during the event.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ2: How does Sileo work to calm dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Sileo contains dexmedetomidine, an alpha 2 adrenoceptor agonist that reduces noradrenaline release in the brain. When applied to the oral mucosa, it is absorbed without first-pass metabolism, producing a calming effect without causing deep sedation in dogs during noise-related stress events.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ3: How often can Sileo be given during a noise event?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e According to manufacturer labeling, Sileo is approved for event-based dosing during noise episodes. Treatment may be repeated if anxiety signs return, with at least two hours between doses, and no more than five doses during a single noise event.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ4: Does Sileo cause heavy sedation in dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Sileo is formulated at a low dose to keep dogs calm without full sedation. Clinical studies reported most dogs remained alert and functional, though some experienced mild drowsiness or temporary sedation, which typically resolved within a few hours after dosing.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ5: How should Sileo be stored after opening?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Manufacturer guidance states that Sileo syringes should be stored at controlled room temperature in their original packaging. Once opened, a syringe may be reused if sufficient gel remains, but contents should be used within four weeks of opening, as labeled.\u003c\/p\u003e","brand":"Zoetis","offers":[{"title":"3 mL","offer_id":44340020150433,"sku":"10015193","price":173.0,"currency_code":"RON","in_stock":true},{"title":"3 mL Bundle of 2","offer_id":44340020183201,"sku":"10015193-2","price":345.0,"currency_code":"RON","in_stock":true},{"title":"3 mL Bundle of 3","offer_id":44340020215969,"sku":"10015195-3","price":517.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/sileo-dexmedetomidine-oromucosal-oromucosal-gel-for-dogs-3-ml-pet-200.jpg?v=1778507633","url":"https:\/\/hordypaw.shop\/en-ro\/products\/pcp-012zoe-5193","provider":"HardyPaw","version":"1.0","type":"link"}