{"product_id":"pcp-012bay01-127","title":"Marquis (15% w\/w ponazuril) Antiprotozoal Oral Paste","description":"\u003ch2\u003eEffective EPM Treatment Paste for Horses\u003c\/h2\u003e\n\u003ch3\u003eProduct Description\u003c\/h3\u003e\n\u003cp\u003eMarquis® (15% ponazuril) is a prescription oral paste formulated to treat Equine Protozoal Myeloencephalitis (EPM) in horses. It targets the underlying protozoal infection while supporting neurological recovery. The easy to administer syringe ensures accurate dosing, including a loading dose for rapid therapeutic levels, making it a reliable and clinically proven solution for managing EPM in horses.\u003c\/p\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTargets Protozoa:\u003c\/strong\u003e Effectively eliminates \u003cem\u003eSarcocystis neurona\u003c\/em\u003e, the primary cause of EPM, addressing the root of neurological disease in horses.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEasy Oral Dosing:\u003c\/strong\u003e Comes in a calibrated syringe paste that allows precise weight-based dosing and convenient daily administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurological Support:\u003c\/strong\u003e Aids in coordination and alleviates neurological deficits, and many horses treated show measurable clinical improvement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProven Effectiveness: \u003c\/strong\u003eClinically proven to be effective, with up to 60 percent of horses treated showing improvement of at least one neurological grade.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRapid Drug Levels:\u003c\/strong\u003e Loading dose strategy helps achieve steady therapeutic concentrations quickly, supporting faster onset of treatment action.\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eVariants\u003c\/h3\u003e\n\u003cp\u003e127 g syringe applicator\u003c\/p\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003cp\u003ePonazuril 150 mg per gram\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003ch4\u003eRecommended-Dosage Chart\u003c\/h4\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"181\"\u003e\n\u003cp\u003e\u003cstrong\u003eHorse Weight\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"194\"\u003e\n\u003cp\u003e\u003cstrong\u003eDay 1 (Loading Dose)\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"204\"\u003e\n\u003cp\u003e\u003cstrong\u003eDay 2–28 (Maintenance Dose)\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"181\"\u003e\n\u003cp\u003e600–1,200 lbs (272–544 kg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"194\"\u003e\n\u003cp\u003e15 mg\/kg (administer 3 times)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"204\"\u003e\n\u003cp\u003e5 mg\/kg once daily\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003eDosage \u0026amp; Administration Instructions\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eInitial Loading Dose:\u003c\/strong\u003e Administer three consecutive doses on the first day to achieve the required 15 mg\/kg loading dose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDaily Maintenance Dose:\u003c\/strong\u003e Continue with a single daily dose of 5 mg\/kg for the remaining 27 days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWeight Adjustment:\u003c\/strong\u003e Use the syringe dosage ring to match the dosage to the horse's body weight, so the dose is correct every time.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProper Administration:\u003c\/strong\u003e Place paste on the back of the tongue and raise the horse’s head briefly to aid swallowing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Required:\u003c\/strong\u003e This medication is restricted to veterinary use and should only be administered under professional supervision.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003eAdditional Information\u003c\/h3\u003e\n\u003ch4\u003ePrecautions\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eConfirm Diagnosis:\u003c\/strong\u003e Make sure the diagnosis of EPM is correct and differentiated from other neurological or musculoskeletal conditions before treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEarly Symptom Worsening:\u003c\/strong\u003e Neurological signs such as ataxia may transiently worsen during the early days of treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIncomplete Recovery:\u003c\/strong\u003e Neurological damage may not be completely reversed by elimination of the parasite, depending on the severity and duration of the disease.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLimited Safety Data:\u003c\/strong\u003e The safety has not been established in breeding horses, pregnant mares, lactating mares, or with other therapies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePossible Side Effects\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin Reactions:\u003c\/strong\u003e Some horses may develop rashes, hives, or skin irritation lasting several days during treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Issues:\u003c\/strong\u003e Loose stools or mild digestive disturbances have been observed in some horses during administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOral Lesions:\u003c\/strong\u003e Blisters around the mouth or nose have been reported in rare cases during treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurological Changes:\u003c\/strong\u003e Temporary worsening of neurological signs, such as ataxia, may occur during early treatment stages.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRare Events:\u003c\/strong\u003e Isolated cases of mild colic or seizures have been reported, though direct association is not confirmed.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eStorage Information\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eControlled Temperature:\u003c\/strong\u003e Store the product at temperatures between 20 and 25 degrees Celsius for optimal stability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllowed Excursions:\u003c\/strong\u003e Short-term storage between 15 and 30 degrees Celsius is acceptable without affecting product quality.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSecure Storage:\u003c\/strong\u003e Keep the syringe tightly capped and stored safely away from children and unauthorized access.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShipping \u0026amp; Return\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, priority, and international delivery; see our \u003ca href=\"\/en-ro\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-ro\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE. \u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eQ1: What is Marquis used for in horses?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Marquis is used to treat Equine Protozoal Myeloencephalitis, a neurological disease caused by Sarcocystis neurona. It targets and removes the protozoal infection. This helps improve neurological function and coordination in affected horses when given as directed by a veterinarian.\u003c\/p\u003e\n\u003ch3\u003eQ2: How long does the Marquis treatment take to show results?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Treatment typically lasts 28 days, and clinical improvement may be observed within weeks. In studies, horses were evaluated up to 118 days, with many showing at least one grade improvement in neurological condition, depending on disease severity and duration before treatment began.\u003c\/p\u003e\n\u003ch3\u003eQ3: How is Marquis paste administered to horses?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Marquis is given by mouth with a calibrated syringe. Place the paste on the back of the horse’s tongue and make sure the mouth is empty of feed. Adjust the dosage based on the horse's body weight. Raise the horse’s head briefly to help with swallowing.\u003c\/p\u003e\n\u003ch3\u003eQ4: Are there any side effects associated with Marquis?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Some horses may experience side effects such as skin rashes, loose stools, oral blisters, or mild colic. In rare cases, neurological signs may temporarily worsen during early treatment. These effects are not always directly linked to the medication but should be monitored.\u003c\/p\u003e\n\u003ch3\u003eQ5: Can Marquis be used in all horses?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Marquis is intended for horses only. It should not be used in horses raised for human consumption. Its safety has not been checked in breeding, pregnant, or lactating horses. Therefore, you should seek veterinary advice before using it in these groups.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Merial","offers":[{"title":"1 syringe","offer_id":43600599154849,"sku":"126672-BI","price":1966.0,"currency_code":"RON","in_stock":true},{"title":"4 syringes","offer_id":43600599187617,"sku":"126674-BI","price":7220.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/marquis-15-w-w-ponazuril-antiprotozoal-oral-paste-pet-medicine-549.png?v=1778505728","url":"https:\/\/hordypaw.shop\/en-ro\/products\/pcp-012bay01-127","provider":"HardyPaw","version":"1.0","type":"link"}