{"product_id":"panoquell-ca1-fuzapladib-sodium-for-injection-14mg-4mg-ml","title":"Panoquell-CA1 (Fuzapladib Sodium) Injection 14mg (4mg\/mL)","description":"\u003cp align=\"center\"\u003e\u003cimg src=\"https:\/\/hordypaw.shop\/cdn\/shop\/files\/rx-map.webp\" class=\"img-responsive\" alt=\"RX MAP\" width=\"700\" data-original=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\" data-files=\"rx-map.jpg\" loading=\"lazy\"\u003e\u003c\/p\u003e\n\u003ch2\u003eTargeted Pancreatitis Support for Dogs\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003ePANOQUELL®-CA1 is an FDA conditionally approved injectable treatment designed to manage clinical signs associated with acute-onset pancreatitis in dogs. Formulated with fuzapladib sodium, it works by inhibiting LFA-1 activation to help reduce inflammatory cell migration and limit pancreatic tissue damage. Administered intravenously for three consecutive days, it complements standard supportive care under veterinary supervision.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTargets Inflammation\u003c\/strong\u003e: Inhibits LFA-1 activation to reduce inflammatory cell adhesion and migration into pancreatic tissue.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Evaluated\u003c\/strong\u003e: Demonstrated statistically significant improvement in clinical scores compared to vehicle control in pilot study.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDesigned for Dogs\u003c\/strong\u003e: Specifically indicated for managing clinical signs of acute-onset pancreatitis in dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIV Administration\u003c\/strong\u003e: Delivered by controlled intravenous bolus for precise dosing under veterinary supervision.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMinimal Accumulation\u003c\/strong\u003e: Shows minimal drug accumulation with repeated once daily dosing in pharmacokinetic studies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eIngredients\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eActive Ingredients\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eFuzapladib sodium.\u003c\/p\u003e\n\u003ch4\u003e\u003cstrong\u003eInactive Ingredients\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eD-mannitol, tromethamine, benzyl alcohol, bacteriostatic water for injection.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eHow to Use\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eRecommended-Dosage Chart\u003c\/strong\u003e\u003c\/h4\u003e\n\u003ctable height=\"5\" style=\"width: 56.2801%;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"145\" style=\"width: 25.3807%;\"\u003e\n\u003cp\u003e\u003cstrong\u003eBody Weight (kg)\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"110\" style=\"width: 19.2605%;\"\u003e\n\u003cp\u003e\u003cstrong\u003eDose (mg\/kg)\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"132\" style=\"width: 23.0407%;\"\u003e\n\u003cp\u003e\u003cstrong\u003eVolume (mL\/kg)\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"99\" style=\"width: 17.2805%;\"\u003e\n\u003cp\u003e\u003cstrong\u003eFrequency\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"135\" style=\"width: 13.6804%;\"\u003e\n\u003cp\u003e\u003cstrong\u003eDuration\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"145\" style=\"width: 25.3807%;\"\u003e\n\u003cp\u003ePer kg body weight\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"110\" style=\"width: 19.2605%;\"\u003e\n\u003cp\u003e0.4 mg\/kg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"132\" style=\"width: 23.0407%;\"\u003e\n\u003cp\u003e0.1 mL\/kg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"99\" style=\"width: 17.2805%;\"\u003e\n\u003cp\u003eOnce daily\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"135\" style=\"width: 13.6804%;\"\u003e\n\u003cp\u003e3 consecutive days\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Administration Instructions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Only\u003c\/strong\u003e: Federal law restricts use to licensed veterinarians or on their order.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution Required\u003c\/strong\u003e: Reconstitute lyophilized powder with 3.5 mL supplied sterile diluent before use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGentle Swirling\u003c\/strong\u003e: Gently swirl the vial until fully dissolved before each subsequent dose withdrawal.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIV Bolus Use\u003c\/strong\u003e: Administer intravenously over 15 seconds to one minute for proper delivery.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrompt Administration\u003c\/strong\u003e: Draw the calculated dose using a sterile syringe and administer immediately after preparation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer: \u003c\/strong\u003eThis dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eAdditional Information\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003ePrecautions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtein-Bound Drug:\u003c\/strong\u003e Use with caution if the dog is taking other medications that bind strongly to proteins, as this may increase the risk of drug interactions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLimited Safety Data:\u003c\/strong\u003e This product has not been studied in dogs with heart disease, liver failure, or kidney problems.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBreeding Status:\u003c\/strong\u003e Its safety has not been evaluated in pregnant, nursing, or breeding dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eYoung Dogs:\u003c\/strong\u003e It has not been studied in dogs younger than six months of age.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHuman Safety\u003c\/strong\u003e: Not for human use and avoid exposure if pregnant or hypersensitive.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003ePossible Side Effects\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Signs:\u003c\/strong\u003e Dogs may throw up, have diarrhea, spit up food, feel nauseous, or develop gut inflammation during treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAppetite Changes:\u003c\/strong\u003e Some dogs in the study ate less than usual or lost their appetite.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHeart-Related Effects:\u003c\/strong\u003e Irregular heartbeat, high blood pressure, and in very rare cases, heart failure were reported.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInjection Reactions\u003c\/strong\u003e: Swelling, bruising, and subcutaneous hemorrhage were noted at injection sites.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypersensitivity Reactions\u003c\/strong\u003e: Pruritus, urticaria, facial swelling, and anaphylaxis have been reported in some cases.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnopened Storage\u003c\/strong\u003e: Store unopened vials at 59°F to 77°F room temperature conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRefrigerated Storage:\u003c\/strong\u003e Keep the reconstituted product refrigerated at 36°F to 46°F.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUse Period:\u003c\/strong\u003e Once the vial has been punctured and mixed, use the solution within 28 days.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eShipping \u0026amp; Return\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, priority, and international delivery; see our \u003ca href=\"\/en-ro\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-ro\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE. \u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eQ1: What is PANOQUELL®-CA1 used for in dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e PANOQUELL®-CA1 is used to help manage the clinical signs of sudden, acute \u003ca href=\"https:\/\/www.niddk.nih.gov\/health-information\/digestive-diseases\/pancreatitis\" target=\"_blank\" rel=\"noopener\" title=\"Pancreatitis - niddk\" aria-label=\"Visit a webpage about Pancreatitis - niddk\"\u003epancreatitis\u003c\/a\u003e in dogs. It’s meant to be part of a complete treatment plan, alongside supportive care like IV fluids, proper nutrition, and pain control, all under the guidance of a veterinarian.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ2: How does PANOQUELL®-CA1 work?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e PANOQUELL®-CA1 contains fuzapladib sodium, a selective inhibitor of leukocyte function-associated antigen-1 activation. Inhibiting LFA-1 reduces inflammatory cell adhesion and migration into pancreatic tissue, helping limit lesion expansion and inflammatory complications.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ3: How is PANOQUELL®-CA1 administered?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e After mixing the powder with the sterile diluent provided, PANOQUELL®-CA1 is given through an IV at a dose of 0.4 mg per kg of body weight. It is administered once a day for three days in a row. Each dose is delivered as a slow IV bolus over about 15 seconds to one minute.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ4: Is PANOQUELL®-CA1 FDA-approved?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e PANOQUELL®-CA1 has received conditional approval from the FDA under application number 141-567 while full effectiveness data is still being completed. This status allows the product to be legally marketed as additional studies continue to confirm its effectiveness.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ5: What side effects have been reported with PANOQUELL®-CA1?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Reported side effects include loss of appetite, digestive or breathing issues, diarrhea, irregular heartbeat, high blood pressure, swelling at the injection site, and allergic reactions such as itching or facial swelling.\u003c\/p\u003e\n\u003cp\u003eSome of these reactions were seen during clinical studies, while others were reported after the product was approved and used in other countries.\u003c\/p\u003e\n\u003ch2\u003eClinical Research\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/animaldrugsatfda.fda.gov\/adafda\/app\/search\/public\/document\/downloadFoi\/13134\" title=\"Https:\/\/animaldrugsatfda.fda.gov\/adafda\/app\/search\/public\/document\/downloadfoi\/13134\" aria-label=\"Visit a webpage about Https:\/\/animaldrugsatfda.fda.gov\/adafda\/app\/search\/public\/document\/downloadfoi\/13134\"\u003ehttps:\/\/animaldrugsatfda.fda.gov\/adafda\/app\/search\/public\/document\/downloadFoi\/13134\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=e2e316bd-ff8b-4d14-a2e8-c518f8b153cb\u0026amp;type=display\" title=\"Https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdadrugxsl.cfm\" aria-label=\"Visit a webpage about Https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdadrugxsl.cfm\"\u003ehttps:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm\u003c\/a\u003e\u003c\/p\u003e","brand":"Ceva","offers":[{"title":"Default Title","offer_id":43707378499745,"sku":"G44310B","price":1740.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/panoquell-ca1-fuzapladib-sodium-injection-14mg-4mg-ml-pet-medicine-679.png?v=1778474424","url":"https:\/\/hordypaw.shop\/en-ro\/products\/panoquell-ca1-fuzapladib-sodium-for-injection-14mg-4mg-ml","provider":"HardyPaw","version":"1.0","type":"link"}