{"product_id":"lisinopril-20mg-and-hydrochlorothiazide-25mg-tablets","title":"Lisinopril 20 mg and Hydrochlorothiazide 25 mg Tablets","description":"\u003cp\u003e\u003cimg loading=\"lazy\" data-files=\"rx-map.jpg\" data-original=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\" width=\"700\" alt=\"RX MAP\" class=\"img-responsive\" src=\"https:\/\/hordypaw.shop\/cdn\/shop\/files\/rx-map.webp\"\u003e\u003c\/p\u003e\n\u003ch2\u003eLisinopril and Hydrochlorothiazide Tablets for Pet Blood Pressure\u003c\/h2\u003e\n\u003ch3\u003eProduct Description\u003c\/h3\u003e\n\u003cp\u003eLisinopril 20 mg and Hydrochlorothiazide 25 mg Tablets are a prescription-only, higher-strength dual-action combination used off-label in dogs and cats when lower-dose antihypertensive therapy has not brought \u003ca href=\"\/en-ro\/collections\/heart-blood-pressure\" title=\"Heart \u0026amp; blood pressure medications for dogs \u0026amp; cats – enalapril, cardalis | hardypaw\" aria-label=\"Heart \u0026amp; blood pressure medications for dogs \u0026amp; cats – enalapril, cardalis | hardypaw\"\u003eblood pressure \u003c\/a\u003eunder adequate control. Lisinopril cuts angiotensin II levels by blocking ACE to relax vessel walls, while hydrochlorothiazide lowers circulatory fluid by pushing excess sodium and water out through the kidneys.\u003c\/p\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigher Strength Option:\u003c\/strong\u003e A stronger option for pets whose high blood pressure has not been adequately controlled by lower-strength antihypertensive combinations.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eACE Inhibition Action:\u003c\/strong\u003e Lisinopril blocks the angiotensin-converting enzyme, cutting angiotensin II levels and letting arteries relax and widen in treated pets.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiuretic Pressure Reduction:\u003c\/strong\u003e Hydrochlorothiazide lowers circulatory fluid volume by driving excess sodium and water out through the kidneys in treated pets.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdvanced Hypertension Control:\u003c\/strong\u003e A more powerful approach for pets whose persistent hypertension has not responded to lower-strength antihypertensive combinations under vet care.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProteinuria Management:\u003c\/strong\u003e Helps reduce abnormal protein leakage into urine associated with glomerular disease and \u003ca href=\"\/en-ro\/collections\/dog-kidney-urinary-medications\" title=\"Dog kidney \u0026amp; urinary tract medications: prevent stones \u0026amp; infections | hardypaw\" aria-label=\"Dog kidney \u0026amp; urinary tract medications: prevent stones \u0026amp; infections | hardypaw\"\u003echronic kidney disease in dogs and cats\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003ch4\u003eActive Ingredients\u003c\/h4\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eIngredient\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eStrength per Tablet\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLisinopril\u003c\/td\u003e\n\u003ctd\u003e20 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eHydrochlorothiazide\u003c\/td\u003e\n\u003ctd\u003e25 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003ch4\u003eDosage \u0026amp; Administration Instructions\u003c\/h4\u003e\n\u003cp\u003eLisinopril 20 mg and Hydrochlorothiazide 25 mg Tablets are a prescription-only medication. A valid veterinarian prescription is required to purchase this product. Please follow your veterinarian's instructions carefully for the dosage and administration of this medication.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e Dosage and administration of this medication must be determined by a licensed veterinarian. Always consult your veterinarian before administering or adjusting any prescription medication for your pet.\u003c\/p\u003e\n\u003cp\u003ePlacing a tablet inside a soft Pill Pocket or wrapping it in a small piece of your pet's favorite treat is a simple and caring way to make each dose easier for both of you. A pill pocket treat takes the stress out of medicating your pet and helps ensure no dose is missed. \u003ca aria-label=\"Shop pill pockets for dogs\" title=\"Shop pill pockets for dogs\" href=\"\/en-ro\/collections\/pill-pockets-for-dogs\"\u003eShop Pill Pockets for Dogs\u003c\/a\u003e | \u003ca aria-label=\"Shop pill pockets for cats\" title=\"Shop pill pockets for cats\" href=\"\/en-ro\/collections\/pill-pockets-for-cats\"\u003eShop Pill Pockets for Cats\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eAdditional Information\u003c\/h3\u003e\n\u003ch4\u003ePrecautions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eACE Inhibitor Allergy:\u003c\/strong\u003e Avoid in pets with a known allergy to lisinopril, enalapril, benazepril, or any other ACE inhibitor medication.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHyperkalemia Risk:\u003c\/strong\u003e This combination may raise blood potassium levels; avoid potassium supplements alongside this product without direct veterinary guidance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSevere Kidney Disease:\u003c\/strong\u003e Both components can further reduce kidney perfusion; use with extra caution in pets with significant renal impairment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLow Blood Volume:\u003c\/strong\u003e Both components push pressure down; avoid in dehydrated pets or those with low blood volume for this reason.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy Caution:\u003c\/strong\u003e Both lisinopril and hydrochlorothiazide may harm fetuses and nursing young; do not use in pregnant or nursing animals.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLupus or Autoimmune History:\u003c\/strong\u003e Flag any history of lupus, blood disorders, or autoimmune conditions to your vet before this product is introduced.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSulfonamide Allergy:\u003c\/strong\u003e Avoid in pets allergic to sulfonamide drugs, as hydrochlorothiazide is chemically related to the sulfonamide medication class.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Interactions:\u003c\/strong\u003e NSAIDs, ARBs, potassium-sparing diuretics, lithium, and cholestyramine all interact with this combination; always keep your vet fully informed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegular Monitoring Required:\u003c\/strong\u003e Blood pressure, kidney values, and electrolytes need checking before starting and regularly throughout the full course of treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Only:\u003c\/strong\u003e No veterinary FDA approval exists for either ingredient; both require a licensed veterinarian's direct order before dispensing.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePossible Side Effects\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eLow Blood Pressure:\u003c\/strong\u003e Weakness, lethargy, or difficulty standing may signal hypotension; contact your vet promptly if any of these signs develop.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKidney Dysfunction:\u003c\/strong\u003e Rising kidney values or shifts in thirst and urination may indicate renal stress from lisinopril in treated pets.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eElectrolyte Imbalances:\u003c\/strong\u003e Hypokalemia, hyponatremia, or hypomagnesemia may develop; watch for muscle weakness, tremors, or irregular heartbeat in treated pets.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVomiting and Diarrhea:\u003c\/strong\u003e Gastrointestinal reactions including vomiting and loose stools are among the more frequently reported side effects in treated pets.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDry Cough:\u003c\/strong\u003e A persistent dry cough may develop in some pets on lisinopril; contact your vet if this sign appears.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Facial swelling, hives, or breathing trouble require stopping this product at once and getting emergency veterinary attention without delay.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eStorage Information\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoom Temperature Storage:\u003c\/strong\u003e Keep sealed at room temperature away from direct light, heat, and moisture to preserve both active ingredients over time.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid Humidity Exposure:\u003c\/strong\u003e Always keep the container firmly closed between uses to prevent humidity from degrading tablet quality throughout the shelf life.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep Out of Reach:\u003c\/strong\u003e Keep this product away from children and other animals; accidental ingestion of either ingredient carries serious health risks.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eNOTE:\u003c\/strong\u003e For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.\u003c\/p\u003e\n\u003ch3\u003eShipping \u0026amp; Return\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, and priority delivery; see our \u003ca aria-label=\"Shipping policy\" title=\"Shipping policy\" href=\"\/en-ro\/pages\/shipping-policy\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca aria-label=\"Refund policy\" title=\"Refund policy\" href=\"\/en-ro\/policies\/refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eQ1: What is the Lisinopril 20 mg and Hydrochlorothiazide 25 mg combination used for in pets?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Used off-label in dogs and cats to manage systemic hypertension not brought under control by lower-strength therapy. Lisinopril relaxes vessel walls by blocking ACE while hydrochlorothiazide reduces fluid volume through renal excretion, addressing two distinct mechanisms behind high blood pressure.\u003c\/p\u003e\n\u003ch3\u003eQ2: Can this combination cause my pet's kidneys to stop working properly?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Yes. Both components can affect kidney function, particularly if blood pressure drops too low or the pet becomes dehydrated. Regular blood tests throughout treatment allow your vet to catch any signs of renal stress before they become a serious problem.\u003c\/p\u003e\n\u003ch3\u003eQ3: Why does this combination also help with kidney disease in pets?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Lisinopril reduces intraglomerular pressure by blocking angiotensin II, helping limit the protein leakage into urine seen with glomerular and chronic kidney disease. This kidney-protective effect is why vets may choose an ACE inhibitor over other antihypertensive options for affected pets.\u003c\/p\u003e\n\u003ch3\u003eQ4: What electrolyte side effects should I watch for in my pet on this combination?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Hydrochlorothiazide can lower potassium, sodium, and magnesium levels in treated pets. Watch for muscle weakness, lethargy, tremors, or an irregular heartbeat as warning signs. Regular blood tests throughout treatment help your vet catch and address any electrolyte imbalances early.\u003c\/p\u003e\n\u003ch3\u003eQ5: Do I need a prescription for Lisinopril 20 mg and Hydrochlorothiazide 25 mg Tablets for my pet?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Yes, this is a prescription-only combination. Neither ingredient carries veterinary FDA approval, and both can only be dispensed on a licensed veterinarian's direct order. Regular monitoring appointments throughout treatment are essential for keeping your pet safe on this product.\u003c\/p\u003e","brand":"Varies (Generic)","offers":[{"title":"1 tablet","offer_id":44430205419681,"sku":"152883-1","price":1.0,"currency_code":"RON","in_stock":true},{"title":"30 tablets","offer_id":44430205452449,"sku":"152883-30","price":19.0,"currency_code":"RON","in_stock":true},{"title":"60 tablets","offer_id":44430205485217,"sku":"152883-60","price":34.0,"currency_code":"RON","in_stock":true},{"title":"100 tablets","offer_id":44430205517985,"sku":"152883","price":53.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/lisinopril-20-mg-and-hydrochlorothiazide-25-tablets-pet-medicine-228.png?v=1778755827","url":"https:\/\/hordypaw.shop\/en-ro\/products\/lisinopril-20mg-and-hydrochlorothiazide-25mg-tablets","provider":"HardyPaw","version":"1.0","type":"link"}