{"product_id":"cyclavance-oral-solution-for-dogs","title":"Cyclavance (cyclosporine) Oral Solution For Dogs - USP Modified 100 mg\/mL","description":"\u003cp\u003e\u003cimg src=\"https:\/\/hordypaw.shop\/cdn\/shop\/files\/rx-map.webp\" class=\"img-responsive\" alt=\"RX MAP\" width=\"700\" data-original=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\" data-files=\"rx-map.jpg\" loading=\"lazy\"\u003e\u003ca href=\"\/en-ro\/products\/cyclavance-oral-solution-for-dogs\" rel=\"noopener\" title=\"Cyclavance (cyclosporine) oral solution for dogs - usp modified 100 mg\" aria-label=\"Cyclavance (cyclosporine) oral solution for dogs - usp modified 100 mg\" target=\"_blank\"\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003ch2\u003eEffective Atopic Dermatitis Relief Oral Solution for Dogs\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eCYCLAVANCE is a veterinary prescription oral cyclosporine solution that helps control atopic dermatitis in dogs. It does this by targeting the immune response that causes \u003ca href=\"\/en-ro\/collections\/dog-skin-medications\" target=\"_blank\" rel=\"noopener\" title=\"Itching and inflammation\" aria-label=\"Itching and inflammation\"\u003eitching and inflammation\u003c\/a\u003e. Its microemulsion formulation supports consistent absorption, which helps reduce scratching, skin lesions, and discomfort. It provides a steroid-free option for long-term allergy management under veterinary supervision. \u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTargets Immune Response: \u003c\/strong\u003eSelectively targets immune cells involved in allergic reactions, which lowers inflammation and itching in affected dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReduces Itching Signs: \u003c\/strong\u003eHelps control scratching, licking, and chewing behaviors linked to canine atopic dermatitis, which improves comfort.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSteroid-Free Therapy: \u003c\/strong\u003eOffers an option to corticosteroids or antihistamines and effectively manages chronic allergic skin disease.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlexible Dosing Schedule: \u003c\/strong\u003eInitial daily dosing can be reduced to less frequent use once clinical improvement is seen.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Proven Results:\u003c\/strong\u003e Studies demonstrated significant improvement in pruritus and skin lesion severity within the first month of therapy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eVariants \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e15 mL vial \u003cbr\u003e50 mL vial\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eIngredients \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eCyclosporine (USP Modified) 100 mg\/mL\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eHow to Use \u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eRecommended-Dosage Chart\u003c\/strong\u003e\u003c\/h4\u003e\n\u003ctable style=\"width: 32.5926%; height: 190px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"178\" style=\"width: 40.5012%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eDog Body Weight\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"260\" style=\"width: 59.2217%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYCLAVANCE Dose Volume\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"178\" style=\"width: 40.5012%; height: 35.5966px;\"\u003e\n\u003cp\u003e2.2 lbs (1 kg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"260\" style=\"width: 59.2217%; height: 35.5966px;\"\u003e\n\u003cp\u003e0.05 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"178\" style=\"width: 40.5012%; height: 35.5966px;\"\u003e\n\u003cp\u003e4.4 lbs (2 kg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"260\" style=\"width: 59.2217%; height: 35.5966px;\"\u003e\n\u003cp\u003e0.1 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"178\" style=\"width: 40.5012%; height: 35.5966px;\"\u003e\n\u003cp\u003e11 lbs (5 kg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"260\" style=\"width: 59.2217%; height: 35.5966px;\"\u003e\n\u003cp\u003e0.25 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"178\" style=\"width: 40.5012%; height: 35.5966px;\"\u003e\n\u003cp\u003e22 lbs (10 kg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"260\" style=\"width: 59.2217%; height: 35.5966px;\"\u003e\n\u003cp\u003e0.5 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"178\" style=\"width: 40.5012%; height: 35.5966px;\"\u003e\n\u003cp\u003e44 lbs (20 kg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"260\" style=\"width: 59.2217%; height: 35.5966px;\"\u003e\n\u003cp\u003e1.0 mL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Administration Instructions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVeterinary Prescription Only: \u003c\/strong\u003eFederal law limits this medication to use by, or on the order of, a licensed veterinarian.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInitial Daily Dose: \u003c\/strong\u003eGive 5 mg\/kg once daily for 30 days before reducing the frequency based on clinical response.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGive Before Meals: \u003c\/strong\u003eAdminister at least one hour before or two hours after feeding for the best absorption and effectiveness.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTapering Schedule: \u003c\/strong\u003eAfter improvement, you can reduce the dosing frequency to every other day or twice a week as directed by the veterinarian.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMissed Dose Instruction:\u003c\/strong\u003e If a dose is missed, give it as soon as possible without doubling or exceeding the once-daily dose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSyringe Handling: \u003c\/strong\u003eDo not rinse or clean the oral dosing syringe between uses to keep dosing accuracy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eAdditional Information \u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003ePrecautions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune Suppression Risk:\u003c\/strong\u003e As a systemic immunosuppressant, treatment may increase susceptibility to infections and the potential development of neoplasia.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eYoung Dog Safety:\u003c\/strong\u003e Safety has not been established in dogs under six months of age or below four pounds body weight.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBreeding Restrictions:\u003c\/strong\u003e Not recommended for breeding, pregnant, or lactating dogs due to insufficient safety data.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiabetes Caution:\u003c\/strong\u003e Use carefully in diabetic dogs since cyclosporine can increase blood glucose levels.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Interactions: \u003c\/strong\u003eUsing this drug with other medications that affect the cytochrome P450 enzyme system may change cyclosporine blood levels.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRenal Conditions: \u003c\/strong\u003eBe cautious when using in dogs with weak kidney function because the effects in kidney insufficiency are not fully studied.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003ePossible Side Effects \u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Upset:\u003c\/strong\u003e Vomiting and diarrhea are the most commonly reported side effects, often resolving with continued treatment or dose adjustments.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReduced Appetite:\u003c\/strong\u003e Some dogs may experience anorexia, weight loss, or lethargy during therapy, requiring veterinary monitoring.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGum Changes:\u003c\/strong\u003e Gingival hyperplasia and swollen gums have been reported, often improving after dose reduction.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInfection Risk:\u003c\/strong\u003e Increased susceptibility to infections such as otitis externa or urinary tract infections may occur.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurological Events:\u003c\/strong\u003e Rare cases of seizures or tremors have been reported in dogs receiving cyclosporine therapy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoom Temperature Storage:\u003c\/strong\u003e Store in the original container at 68°F to 86°F (20°C to 30°C).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid Refrigeration:\u003c\/strong\u003e Do not refrigerate because precipitation may occur if stored below the recommended temperature range.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUse After Opening:\u003c\/strong\u003e Once opened, contents should be used within 12 weeks for safety and effectiveness.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep Secure:\u003c\/strong\u003e Keep out of reach of children and store medication and dosing syringe safely after each use.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eShipping \u0026amp; Return  \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, priority, and international delivery; see our \u003ca href=\"\/en-ro\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details. \u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-ro\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.  \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eQ1: What is CYCLAVANCE used for in dogs? \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e CYCLAVANCE is prescribed to control atopic dermatitis in dogs weighing at least 4 lbs by reducing immune-related inflammation and itching. It helps manage symptoms such as scratching, licking, and skin lesions caused by environmental allergens. Treatment should always be supervised by a licensed veterinarian.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ2: How long does CYCLAVANCE take to work in dogs? \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Improvement is usually seen within 30 days of starting daily therapy. Once symptoms are under control, veterinarians may lower the dosing frequency to keep it effective. Response time can differ among dogs, so ongoing veterinary monitoring and dose adjustments are important for the best long-term management.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ3: How should CYCLAVANCE be given to dogs? \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e CYCLAVANCE should be given by mouth using the provided dosing syringe at least one hour before or two hours after meals. Owners should not change the dosing schedule without asking a vet to ensure safe and effective treatment.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ4: What are the most common side effects of CYCLAVANCE? \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e The most common side effects are vomiting and diarrhea. These usually improve with ongoing use or changes in dosage. Some other potential effects include lethargy, reduced appetite, swollen gums, and infections. Consult a veterinarian if any worrisome symptoms arise during treatment.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ5: Can CYCLAVANCE be used with other medications? \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e CYCLAVANCE may interact with medications that affect the cytochrome P450 enzyme system, including certain antifungals like ketoconazole. Owners should inform veterinarians about all medications and supplements their dog receives to avoid interactions and ensure safe concurrent use when necessary. \u003cbr\u003e\u003c\/p\u003e\n\u003ch2\u003eClinical Research:\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.proquest.com\/openview\/cd41b8a7de963f0f6cb5b8c5c8ee48c0\/1?pq-origsite=gscholar\u0026amp;cbl=18750\u0026amp;diss=y\" title=\"Cyclosporine populational pharmacodynamic studies in dogs - proquest\" aria-label=\"Visit a webpage about Cyclosporine populational pharmacodynamic studies in dogs - proquest\"\u003ehttps:\/\/www.proquest.com\/openview\/cd41b8a7de963f0f6cb5b8c5c8ee48c0\/1?pq-origsite=gscholar\u0026amp;cbl=18750\u0026amp;diss=y\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1186\/s12917-016-0669-9?error=cookies_not_supported\u0026amp;code=bc158d83-1b4c-4e0e-a817-1e9a82b58c25\" title=\"Bioequivalence study between two formulations of ciclosporin a (cyclavance® oral solution and atopica® soft capsules) following a single oral administration to dogs | bmc veterinary research | springer nature link\" aria-label=\"Visit a webpage about Bioequivalence study between two formulations of ciclosporin a (cyclavance® oral solution and atopica® soft capsules) following a single oral administration to dogs | bmc veterinary research | springer nature link\"\u003ehttps:\/\/link.springer.com\/article\/10.1186\/s12917-016-0669-9\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Virbac","offers":[{"title":"1 Count (15-mL)","offer_id":44300081987745,"sku":"VC02-0301","price":484.0,"currency_code":"RON","in_stock":true},{"title":"2 Count (15-mL)","offer_id":44300082020513,"sku":"VC02-0301-PK2","price":968.0,"currency_code":"RON","in_stock":true},{"title":"1 Count (50-mL)","offer_id":44300082053281,"sku":"VC02-0303","price":1159.0,"currency_code":"RON","in_stock":true},{"title":"2 Count (50-mL)","offer_id":44300082086049,"sku":"VC02-0303-PK2","price":2318.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/cyclavance-cyclosporine-oral-solution-for-dogs-usp-modified-100-479.jpg?v=1777918399","url":"https:\/\/hordypaw.shop\/en-ro\/products\/cyclavance-oral-solution-for-dogs","provider":"HardyPaw","version":"1.0","type":"link"}