{"product_id":"cardalis-20mg-2-5-mg-chewable-tablets-1","title":"Cardalis Chewable Tablets for Dogs (Spironolactone\/Benazepril Hydrochloride) - 20mg\/2.5mg","description":"\u003cp\u003e\u003cimg width=\"700\" alt=\"RX MAP\" class=\"img-responsive\" src=\"https:\/\/hordypaw.shop\/cdn\/shop\/files\/rx-map.webp\" data-original=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\" data-files=\"rx-map.jpg\" loading=\"lazy\"\u003e\u003c\/p\u003e\n\u003ch2\u003eDual-Action Congestive Heart Failure Support for Dogs\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eCardalis (20 mg spironolactone \/ 2.5 mg benazepril hydrochloride) is a flavored chewable tablet formulated for dogs with congestive heart failure caused by atrioventricular valvular insufficiency. It combines spironolactone and benazepril hydrochloride to target the renin-angiotensin-aldosterone system at multiple levels. Used alongside therapies such as furosemide, it helps manage clinical signs of mild, moderate, and severe heart failure with once daily, weight-based dosing.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDual RAAS Blockade\u003c\/strong\u003e: Combines spironolactone and benazepril to inhibit both ACE and non-ACE aldosterone pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProven Clinical Effectiveness\u003c\/strong\u003e: Demonstrated statistically lower treatment failure rates compared to benazepril alone in a 360-day study.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExtended Time-to-Failure\u003c\/strong\u003e: Dogs treated with Cardalis showed a longer median time-to-treatment failure versus the control group.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOnce Daily Dosing\u003c\/strong\u003e: Administered orally once daily with food using scored tablets for accurate weight-based dosing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh Palatability\u003c\/strong\u003e: Voluntarily accepted in 87.6 percent of administered doses during field study evaluation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcurrent Therapy Compatible\u003c\/strong\u003e: Safely administered alongside furosemide, digoxin, calcium channel blockers, and other supportive treatments.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eVariants\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e20 mg spironolactone \/ 2.5 mg benazepril hydrochloride chewable tablets\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-ro\/products\/cardalis-40mg-5mg-chewable-tablets\" title=\"40 mg spironolactone\" aria-label=\"40 mg spironolactone\"\u003e40 mg spironolactone\u003c\/a\u003e \/ 5 mg benazepril hydrochloride chewable tablets\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"\/en-ro\/products\/cardalis-80mg-10mg-chewable-tablets\" title=\"80 mg spironolactone\" aria-label=\"80 mg spironolactone\"\u003e80 mg spironolactone \u003c\/a\u003e\/ 10 mg benazepril hydrochloride chewable tablets\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eIngredients\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eComposition Table\u003c\/strong\u003e\u003c\/h4\u003e\n\u003ctable style=\"width: 43.813%; height: 53px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"206\" style=\"width: 66.9619%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eIngredient\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"101\" style=\"width: 32.7609%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eQuantity\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"206\" style=\"width: 66.9619%; height: 35.5966px;\"\u003e\n\u003cp\u003eSpironolactone\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"101\" style=\"width: 32.7609%; height: 35.5966px;\"\u003e\n\u003cp\u003e20 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"206\" style=\"width: 66.9619%; height: 35.5966px;\"\u003e\n\u003cp\u003eBenazepril Hydrochloride\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"101\" style=\"width: 32.7609%; height: 35.5966px;\"\u003e\n\u003cp\u003e2.5 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003e\u003cstrong\u003eHow to Use\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Administration Instructions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStabilize Pulmonary Edema\u003c\/strong\u003e: Begin treatment only after pulmonary edema has been properly stabilized.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWeight-Based Dosing\u003c\/strong\u003e: Administer 2 mg\/kg spironolactone and 0.25 mg\/kg benazepril hydrochloride once daily, equivalent to 0.9 mg\/lb and 0.11 mg\/lb, respectively.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOral Administration\u003c\/strong\u003e: Give tablets orally using an appropriate combination of whole or half-scored tablets.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdminister With Food\u003c\/strong\u003e: Always provide Cardalis with food to ensure consistent absorption of spironolactone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Required\u003c\/strong\u003e: Federal law restricts this medication to use by or on order of a licensed veterinarian.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eAdditional Information\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003ePrecautions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonitor Potassium Levels\u003c\/strong\u003e: Evaluate renal function and serum potassium before and during treatment due to hyperkalemia risk.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNSAID Caution\u003c\/strong\u003e: Avoid concurrent NSAIDs in dogs with renal insufficiency to reduce renal toxicity risk.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHepatic Dysfunction\u003c\/strong\u003e: Use carefully in dogs with liver impairment due to extensive hepatic biotransformation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigoxin Interaction\u003c\/strong\u003e: Monitor closely when combined with digoxin, as spironolactone may increase digoxin plasma concentrations.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNot Evaluated Groups\u003c\/strong\u003e: Safety not established in pregnant, lactating, breeding, or growing dogs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003ePossible Side Effects\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLoss of Appetite:\u003c\/strong\u003e Some dogs showed a reduced appetite during the 360 day clinical study.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVomiting:\u003c\/strong\u003e Vomiting was reported in dogs that received the treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLow Energy:\u003c\/strong\u003e A few dogs seemed less active than usual during the treatment period.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiarrhea:\u003c\/strong\u003e Some dogs experienced stomach upset, including diarrhea.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKidney Concerns:\u003c\/strong\u003e Kidney issues were reported more often compared to dogs treated with benazepril alone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigher Potassium Levels:\u003c\/strong\u003e Potassium levels were higher in treated dogs, but they still stayed within the normal range.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage Temperature:\u003c\/strong\u003e Keep the tablets at room temperature, between 20°C and 25°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShort-Term Changes:\u003c\/strong\u003e Brief temperature changes between 15°C and 30°C are acceptable if needed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep in Original Packaging:\u003c\/strong\u003e Store the tablets in their original container to help maintain their stability and quality.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eShipping \u0026amp; Return\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, priority, and international delivery; see our \u003ca href=\"\/en-ro\/pages\/shipping-policy\" title=\"Shipping policy\" aria-label=\"Shipping policy\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-ro\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE. \u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eQ1: What is Cardalis 20 mg\/2.5 mg used for in dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Cardalis 20 mg spironolactone and 2.5 mg benazepril hydrochloride tablets are used to help manage the signs of mild, moderate, or severe congestive heart failure in dogs caused by atrioventricular valve disease. They are typically given along with other treatments, such as furosemide, as part of a complete care plan.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ2: What strengths are in the Cardalis 20 mg\/2.5 mg tablet?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Each flavored, scored chewable tablet contains 20 mg of spironolactone and 2.5 mg of benazepril hydrochloride in a fixed 8:1 ratio. Tablets are designed for accurate weight-based dosing using whole or half-tablet increments.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ3: How should Cardalis 20 mg\/2.5 mg be administered?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Cardalis 20 mg\/2.5 mg tablets should be given orally once daily at 2 mg\/kg spironolactone and 0.25 mg\/kg benazepril hydrochloride. Dosing must begin after pulmonary edema is stabilized, and tablets should always be administered with food.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ4: Is Cardalis proven effective compared to benazepril alone?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e In a 360-day U.S. field study involving 569 dogs, Cardalis demonstrated a statistically significant lower treatment failure rate compared to benazepril alone. Dogs treated with Cardalis also showed a longer median time-to-treatment failure.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ5: What side effects were reported with Cardalis?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e In a 360 day U.S. field study, the most commonly reported side effects were loss of appetite, vomiting, tiredness, diarrhea, and kidney problems. Dogs that received the treatment also showed higher potassium and magnesium levels, but the average levels stayed within the normal range.\u003c\/p\u003e","brand":"Ceva","offers":[{"title":"1 tablet","offer_id":43206372589729,"sku":"C63510O-1","price":8.0,"currency_code":"RON","in_stock":true},{"title":"30 tablets","offer_id":43206372655265,"sku":"C63510O","price":224.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/cardalis-chewable-tablets-for-dogs-spironolactone-benazepril-960.png?v=1778526406","url":"https:\/\/hordypaw.shop\/en-ro\/products\/cardalis-20mg-2-5-mg-chewable-tablets-1","provider":"HardyPaw","version":"1.0","type":"link"}