{"product_id":"incurin-tablets-1mg","title":"Incurin (Estriol) Tablets - Incontinence Medication for Dogs - 1 mg","description":"\u003ch2\u003e\u003cstrong\u003eHormone Therapy for Female Dog Incontinence \u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Description \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eINCURIN Tablets are FDA-approved estriol tablets formulated to control estrogen-responsive urinary incontinence in spayed female dogs. Each tablet contains 1 mg of estriol and is administered once daily with dose adjustments based on response. This short-acting natural estrogen helps improve urethral muscle tone while limiting long-term estrogenic risks. Prescription required.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eControls Urinary Leakage\u003c\/strong\u003e: Indicated to manage estrogen-responsive urinary incontinence in ovariohysterectomized female dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImproves Urethral Tone\u003c\/strong\u003e: Estriol increases resting urethral muscle tone to support bladder control in affected dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlexible Dosing Plan\u003c\/strong\u003e: Dose is not weight-based and can be reduced stepwise to determine the lowest effective amount.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShort-Acting Estrogen\u003c\/strong\u003e: Short receptor occupancy time limits prolonged estrogen exposure compared to other estrogens.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Proven Effectiveness\u003c\/strong\u003e: Demonstrated statistically significant improvement over placebo in controlled field studies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eIngredients \u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eComposition Table\u003c\/strong\u003e\u003c\/h4\u003e\n\u003ctable style=\"width: 28.8525%; height: 34px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"110\" style=\"width: 45.0013%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eIngredient\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"134\" style=\"width: 54.7216%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eQuantity\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"110\" style=\"width: 45.0013%; height: 35.5966px;\"\u003e\n\u003cp\u003eEstriol\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"134\" style=\"width: 54.7216%; height: 35.5966px;\"\u003e\n\u003cp\u003e1 mg per tablet\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003e\u003cstrong\u003eHow to Use \u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eRecommended-Dosage Chart\u003c\/strong\u003e\u003c\/h4\u003e\n\u003ctable style=\"width: 51.8276%; height: 204px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"123\" style=\"width: 21.9606%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eStage\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"201\" style=\"width: 35.821%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eDosage\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"97\" style=\"width: 17.2805%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eFrequency\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"135\" style=\"width: 24.1207%; height: 35.5966px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eDuration\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"123\" style=\"width: 21.9606%; height: 35.5966px;\"\u003e\n\u003cp\u003eInitial Therapy\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"201\" style=\"width: 35.821%; height: 35.5966px;\"\u003e\n\u003cp\u003e2 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"97\" style=\"width: 17.2805%; height: 35.5966px;\"\u003e\n\u003cp\u003eOnce daily\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"135\" style=\"width: 24.1207%; height: 35.5966px;\"\u003e\n\u003cp\u003eMinimum 14 days\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 55.1989px;\"\u003e\n\u003ctd width=\"123\" style=\"width: 21.9606%; height: 55.1989px;\"\u003e\n\u003cp\u003eFirst Reduction\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"201\" style=\"width: 35.821%; height: 55.1989px;\"\u003e\n\u003cp\u003e1 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"97\" style=\"width: 17.2805%; height: 55.1989px;\"\u003e\n\u003cp\u003eOnce daily\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"135\" style=\"width: 24.1207%; height: 55.1989px;\"\u003e\n\u003cp\u003eAfter control achieved\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"123\" style=\"width: 21.9606%; height: 35.5966px;\"\u003e\n\u003cp\u003eFurther Reduction\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"201\" style=\"width: 35.821%; height: 35.5966px;\"\u003e\n\u003cp\u003e0.5 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"97\" style=\"width: 17.2805%; height: 35.5966px;\"\u003e\n\u003cp\u003eOnce daily\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"135\" style=\"width: 24.1207%; height: 35.5966px;\"\u003e\n\u003cp\u003eBased on response\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 55.1989px;\"\u003e\n\u003ctd width=\"123\" style=\"width: 21.9606%; height: 55.1989px;\"\u003e\n\u003cp\u003eMaintenance Option\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"201\" style=\"width: 35.821%; height: 55.1989px;\"\u003e\n\u003cp\u003eDetermined lowest effective dose\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"97\" style=\"width: 17.2805%; height: 55.1989px;\"\u003e\n\u003cp\u003eEvery other day\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"135\" style=\"width: 24.1207%; height: 55.1989px;\"\u003e\n\u003cp\u003eAfter stabilization\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5966px;\"\u003e\n\u003ctd width=\"123\" style=\"width: 21.9606%; height: 35.5966px;\"\u003e\n\u003cp\u003eMaximum Dose\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"201\" style=\"width: 35.821%; height: 35.5966px;\"\u003e\n\u003cp\u003e2 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"97\" style=\"width: 17.2805%; height: 35.5966px;\"\u003e\n\u003cp\u003eOnce daily\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"135\" style=\"width: 24.1207%; height: 35.5966px;\"\u003e\n\u003cp\u003eDo not exceed\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Administration Instructions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eInitial Dose\u003c\/strong\u003e: Administer 2 mg orally once daily for a minimum of 14 days.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStepwise Reduction\u003c\/strong\u003e: Decrease dose gradually to 1 mg or 0.5 mg once daily after continence is achieved.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdjustment Interval\u003c\/strong\u003e: Allow at least seven days between each dose adjustment to assess response.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMaximum Limit\u003c\/strong\u003e: Do not administer more than 2 mg per dog per day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiagnosis Review\u003c\/strong\u003e: Reassess diagnosis if no response is observed at a 2 mg daily dose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Required\u003c\/strong\u003e: Federal law allows this drug to be used only by a licensed veterinarian or with their prescription.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eAdditional Information \u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003ePrecautions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvaluate Underlying Causes\u003c\/strong\u003e: Assess contributing factors of urinary incontinence before initiating treatment with INCURIN Tablets.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid Other Estrogens\u003c\/strong\u003e: Do not use concurrently with other estrogen products, as safety has not been evaluated.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiver Disease Caution\u003c\/strong\u003e: Use has not been evaluated in dogs diagnosed with liver disease.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNot For Intact Dogs\u003c\/strong\u003e: Safety not established in intact females, pregnant, lactating, male, or dogs under one year.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003ePossible Side Effects\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Effects:\u003c\/strong\u003e Dogs may lose their appetite, vomit, or drink more water during treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVulvar Changes:\u003c\/strong\u003e Swelling, vaginal inflammation, or excessive licking of the vulva may occur.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBehavioral Changes:\u003c\/strong\u003e Some dogs may show anxiety, aggression, overactivity, or sleepiness.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMammary Changes:\u003c\/strong\u003e Enlarged mammary glands have been seen in clinical and long-term studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHair Loss:\u003c\/strong\u003e Some dogs have experienced hair loss, either in specific areas or all over, based on post-market reports.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoom Temperature Storage\u003c\/strong\u003e: Store at or below 25°C or 77°F under normal conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExcursion Allowance\u003c\/strong\u003e: Temperature excursions permitted up to 40°C or 104°F.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eShipping \u0026amp; Return \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, priority, and international delivery; see our \u003ca href=\"\/en-hk\/pages\/shipping-policy\" title=\"Shipping policy\" aria-label=\"Shipping policy\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-hk\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE. \u003c\/strong\u003e \u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eFrequently Asked Questions \u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eQ1: What is INCURIN used for in dogs? \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e INCURIN® Tablets are designed to help manage urinary incontinence in spayed female dogs caused by estrogen deficiency. They work by controlling leakage that can occur after spaying and are specifically approved by the FDA under NADA 141-325 for this purpose.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ2: How long does it take for INCURIN to start working? \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e In a placebo-controlled field study, treatment success was evaluated after 14 days of once daily 2 mg dosing. A statistically significant improvement compared to placebo was observed at Day 14, indicating a response may be seen within two weeks of therapy.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ3: What is the recommended starting dose of INCURIN? \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e All dogs should receive an initial dose of 2 mg once daily for a minimum of 14 days. The dose is not based on body weight. After urinary control is achieved, the dosage may be reduced stepwise to determine the lowest effective dose.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ4: What are the possible side effects of INCURIN in dogs? \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Reported side effects include loss of appetite, vomiting, swollen vulva, vaginal inflammation, tiredness, enlarged mammary glands, and changes in behavior. After the product was on the market, hair loss and rare blood changes were also reported. In clinical studies, side effects usually increased with higher doses.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ5: Is INCURIN safe for all female dogs? \u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e The safe use of INCURIN has not been evaluated in intact females, pregnant or lactating dogs, male dogs, or dogs under one year of age. It has also not been evaluated in dogs with liver disease or when used with other estrogens.\u003c\/p\u003e","brand":"Merck Animal Health","offers":[{"title":"30 tablets","offer_id":44537760678049,"sku":"162700","price":215.0,"currency_code":"HKD","in_stock":true},{"title":"60 tablets","offer_id":44537760710817,"sku":"162700-2PK","price":430.0,"currency_code":"HKD","in_stock":true},{"title":"90 tablets","offer_id":44537760743585,"sku":"162700-3PK","price":645.0,"currency_code":"HKD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/incurin-estriol-tablets-incontinence-medication-for-dogs-1-mg-pet-493.jpg?v=1778104026","url":"https:\/\/hordypaw.shop\/en-hk\/products\/incurin-tablets-1mg","provider":"HardyPaw","version":"1.0","type":"link"}