{"product_id":"pcp-012ved-ace25-100","title":"PromAce (acepromazine) 25mg, 100 tablets","description":"\u003ch2\u003eFDA-Approved Phenothiazine Tranquilizer and Preanesthetic Tablet for Dogs\u003c\/h2\u003e\n\n\u003ch3\u003eProduct Description\u003c\/h3\u003e\n\u003cp\u003ePromAce (Acepromazine Maleate) Tablets 25 mg are FDA-approved prescription phenothiazine neuroleptic tablets for use in dogs only. Each quarter-scored tablet contains 25 mg acepromazine maleate — a potent CNS depressant that causes sedation, muscular relaxation, and a reduction in spontaneous activity by blocking dopamine receptors in the brain. It is indicated as an aid in tranquilization and as a preanesthetic agent in dogs, and can help manage intractable animals during examinations, grooming, x-rays, and minor surgical procedures. Supplied in bottles of 100 tablets, PromAce is a registered trademark of Boehringer Ingelheim Animal Health USA Inc.\u003c\/p\u003e\n\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul type=\"disc\"\u003e\n  \u003cli\u003e\n\u003cstrong\u003eEffective Canine Tranquilization:\u003c\/strong\u003e Produces a prompt, pronounced calming effect in dogs with rapid onset, making examinations and procedures less stressful for patients and veterinary staff.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eLowers General Anesthetic Requirements:\u003c\/strong\u003e As an effective preanesthetic agent, acepromazine reduces the total dose of general anesthetic needed, supporting smoother induction and recovery.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNo Hypnotic Effect:\u003c\/strong\u003e Unlike sedative-hypnotics, acepromazine produces sedation and muscle relaxation without a hypnotic state, keeping the dog calm yet responsive during procedures.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eQuarter-Scored Tablet for Precise Dosing:\u003c\/strong\u003e Each 25 mg tablet is quarter-scored, allowing it to be split into 6.25 mg increments so doses can be accurately adjusted to the dog's body weight.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eWide Safety Margin:\u003c\/strong\u003e Safety studies showed no adverse reactions in dogs given three times the upper recommended dose (3.0 mg\/lb); the only observation was mild, self-resolving depression.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eAids Procedure Compliance:\u003c\/strong\u003e Helps control intractable dogs during grooming, x-ray positioning, examination, and minor procedures where voluntary cooperation is not possible.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003ch4\u003eActive Ingredients\u003c\/h4\u003e\n\u003cp\u003eAcepromazine Maleate: 25 mg per tablet\u003c\/p\u003e\n\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003ch4\u003eDosage and Administration Instructions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n  \u003cli\u003e\n\u003cstrong\u003ePrescription Required:\u003c\/strong\u003e Federal law restricts PromAce Tablets to use by or on the order of a licensed veterinarian only.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eFor Dogs Only:\u003c\/strong\u003e PromAce Tablets are FDA-approved for use in dogs only; the tablet form is not approved for cats, horses, or any other species.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eDog Dose Range:\u003c\/strong\u003e Give 0.25 to 1.0 mg per lb of body weight orally; always start at the lower end (0.25 mg\/lb) and titrate upward only as needed.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eTiming Before Procedure:\u003c\/strong\u003e Give 45 to 60 minutes before the procedure or event for which tranquilization is needed to allow full effect to develop.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eAllow 15 Minutes for Effect After IV Route:\u003c\/strong\u003e When the injectable form is used by the veterinarian via IV, a minimum of 15 minutes must be allowed before assessing the full sedative effect.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eDose May Be Repeated:\u003c\/strong\u003e The dose may be repeated as required based on clinical response and veterinary judgment.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eReduce Dose in Debilitated or Sensitive Dogs:\u003c\/strong\u003e Use smaller doses with extra caution in dogs that are stressed, debilitated, suffering from cardiac disease, hypovolemia, or shock.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNo Reversal Agent Exists:\u003c\/strong\u003e There is no pharmacological reversal agent for acepromazine; treated dogs must be monitored closely throughout the full duration of effect, which can last 6-12 hours.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\n\u003ch3\u003eAdditional Information\u003c\/h3\u003e\n\n\u003ch4\u003ePrecautions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n  \u003cli\u003e\n\u003cstrong\u003eDo Not Use with Organophosphates:\u003c\/strong\u003e Phenothiazines potentiate organophosphate toxicity; never use PromAce alongside organophosphate vermifuges, ectoparasiticides, or flea collars.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eDo Not Use with Procaine Hydrochloride:\u003c\/strong\u003e Acepromazine must not be used together with procaine hydrochloride due to potential serious drug interaction.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eEpinephrine is Contraindicated:\u003c\/strong\u003e Do not administer epinephrine to dogs receiving acepromazine, as this combination can cause a dangerous paradoxical drop in blood pressure.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eCNS Depressant Potentiation:\u003c\/strong\u003e PromAce is additive with other CNS depressants; reduce doses of any concurrently administered sedatives, anesthetics, or depressants accordingly.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMDR1 Gene Mutation Sensitivity:\u003c\/strong\u003e Dogs carrying the MDR1 gene mutation (common in Collies and related breeds) may be more sensitive to acepromazine; use with extra caution and at the lower end of the dose range.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eLiver Disease Caution:\u003c\/strong\u003e Acepromazine is metabolized by the liver; use with caution in dogs with hepatic impairment as drug effect may be prolonged.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNot for Aggressive Dogs as Sole Agent:\u003c\/strong\u003e Acepromazine does not provide reliable anxiolysis; in dogs with fear-based aggression it should not be used as the sole management agent.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eKeep Out of Reach:\u003c\/strong\u003e Store in a locked location away from children and all animals to prevent accidental ingestion.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch4\u003ePossible Side Effects\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMild Depression:\u003c\/strong\u003e At elevated doses, the only consistent observation in safety studies was mild depression that resolved on its own within 24 hours of stopping the drug.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eTransient Respiratory Distress:\u003c\/strong\u003e A very mild reverse sneeze was the only adverse reaction observed in clinical trials; it was transient and did not affect the drug's intended action.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eIdiosyncratic Behavioral Reactions:\u003c\/strong\u003e Rare but serious reactions including aggression, biting or chewing, and nervousness have been reported in dogs following oral acepromazine administration.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eProlonged Sedation:\u003c\/strong\u003e Excessive doses or administration to sensitive individuals can produce prolonged depression; duration of effect may exceed 12 hours in older dogs or those with liver or kidney disease.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eMotor Restlessness:\u003c\/strong\u003e Excessive amounts given to some dogs may produce motor restlessness rather than the desired calming effect.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch4\u003eStorage Information\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n  \u003cli\u003e\n\u003cstrong\u003eControlled Room Temperature:\u003c\/strong\u003e Store at 20-25°C (68-77°F); excursions between 15-30°C (59-86°F) are permitted without affecting tablet stability or potency.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eKeep Out of Reach:\u003c\/strong\u003e Store in a secure, locked location away from children and all pets to prevent any accidental access to these CNS-active tablets.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eShipping \u0026amp; Return\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, and priority delivery; see our \u003ca href=\"\/en-gb\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-gb\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\n\u003ch3\u003eQ1: What is PromAce acepromazine 25 mg used for in dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e PromAce Tablets are FDA-approved for use in dogs as a tranquilizing and preanesthetic agent. They help manage intractable dogs during examinations, grooming, x-rays, and minor procedures, and reduce the amount of general anesthetic needed when used as a preanesthetic. The tablet form is approved for dogs only.\u003c\/p\u003e\n\n\u003ch3\u003eQ2: What is the correct dose of PromAce acepromazine tablets for dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e The recommended dose is 0.25 to 1.0 mg per lb of body weight given orally. Always begin at the lowest end of the range (0.25 mg\/lb) and increase only if necessary. The quarter-scored 25 mg tablet can be split into 6.25 mg increments for accurate weight-based dosing. The dose can be repeated as required under veterinary direction.\u003c\/p\u003e\n\n\u003ch3\u003eQ3: Why must epinephrine never be given to a dog that received acepromazine PromAce?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Acepromazine blocks alpha-adrenergic receptors, and when epinephrine is given in this state, only the beta-adrenergic vasodilatory effects of epinephrine remain active. This reversal causes a dangerous paradoxical drop in blood pressure rather than the intended vasopressor response, posing a serious risk to the dog.\u003c\/p\u003e\n\n\u003ch3\u003eQ4: Can PromAce acepromazine tablets be used alongside flea collars or other organophosphate products?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e No. Phenothiazine drugs like acepromazine are known to potentiate organophosphate toxicity. PromAce must never be used alongside organophosphorus vermifuges, ectoparasiticides, or flea collars. Always inform the vet of all current parasite control products the dog is wearing or receiving before acepromazine is administered.\u003c\/p\u003e\n\n\u003ch3\u003eQ5: How long does PromAce acepromazine sedation last in dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e The typical duration of acepromazine's sedative effect in dogs is 6 to 8 hours. In older dogs, or those with liver or kidney conditions, effects can persist beyond 12 hours. No pharmacological reversal agent exists for acepromazine, so dogs must be monitored closely throughout the entire period of sedation.\u003c\/p\u003e","brand":"Boehringer Ingelheim","offers":[{"title":"Default Title","offer_id":44370266980513,"sku":"078658552","price":82.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/promace-acepromazine-25mg-100-tablets-pet-medicine-169.jpg?v=1778507579","url":"https:\/\/hordypaw.shop\/en-gb\/products\/pcp-012ved-ace25-100","provider":"HardyPaw","version":"1.0","type":"link"}