{"product_id":"cyproheptadine-tablets-4mg","title":"Cyproheptadine (generic) Tablets - Antihistamine for Dogs \u0026 Cats, 4 mg","description":"\u003cp\u003e\u003cimg loading=\"lazy\" data-files=\"rx-map.jpg\" data-original=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\" src=\"https:\/\/hordypaw.shop\/cdn\/shop\/files\/rx-map.webp\" class=\"img-responsive\" alt=\"RX MAP\" width=\"700\"\u003e\u003c\/p\u003e\n\u003ch2\u003eAntihistamine and Appetite Stimulant Tablets for Allergies and Serotonin Syndrome in Pets\u003c\/h2\u003e\n\u003ch3\u003eProduct Description\u003c\/h3\u003e\n\u003cp\u003eCyproheptadine HCl 4mg Tablets are a prescription first-generation antihistamine with antiserotonergic properties used by veterinarians for dogs and cats. Where standard antihistamines stop at histamine H1 receptors, cyproheptadine also takes on serotonin receptors in the gastrointestinal tract and central nervous system, opening up a broader range of veterinary uses. It covers allergic conditions including feline asthma and atopy, serves as an appetite stimulant for cats and dogs eating poorly, and works as an antidote for serotonin syndrome from drug toxicity or overdose. It is used entirely off-label in veterinary medicine and should be given with food.\u003c\/p\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eFeline Appetite Stimulation:\u003c\/strong\u003e Among the most commonly reached-for appetite stimulants for cats dealing with poor food intake from illness, stress, or chronic disease.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergy and Asthma Relief:\u003c\/strong\u003e Goes after allergic skin conditions, atopy, and feline bronchial asthma by getting in the way of the histamine response driving these conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSerotonin Syndrome Antidote:\u003c\/strong\u003e Steps in against dangerous serotonin toxicity by occupying serotonin receptors, playing a key role in emergency management of serotonin syndrome in pets.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCanine Cushing's Disease Support:\u003c\/strong\u003e Brought into management protocols for pituitary-dependent Cushing's disease in dogs off-label, drawing on its antiserotonergic effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUrine Spraying Reduction in Cats:\u003c\/strong\u003e Sometimes paired with other behavioral medications to help dial down stress-driven urine spraying and marking behavior in cats.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003ch4\u003eActive Ingredients\u003c\/h4\u003e\n\u003cp\u003eCyproheptadine Hydrochloride 4mg\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cp\u003eCyproheptadine HCl 4mg Tablets are a prescription-only medication. A valid veterinarian prescription is required to purchase this product.\u003c\/p\u003e\n\u003cp\u003ePlease follow your veterinarian's specific instructions for the dosage and administration of this medication for your pet.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e Dosage and administration of this medication must be determined by a licensed veterinarian. Always consult your veterinarian before administering or adjusting any prescription medication for your pet.\u003c\/p\u003e\n\u003cp\u003eTucking it into a soft pill pocket or pill wrap treat alongside a small meal is a simple way to get your pet to take their dose comfortably.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"\/en-gb\/collections\/dog-pill-pockets\" title=\"Dog pill pockets \u0026amp; wraps: best easy pill-giving solutions | hardypaw\" aria-label=\"Dog pill pockets \u0026amp; wraps: best easy pill-giving solutions | hardypaw\"\u003eShop Pill Pockets for Dogs\u003c\/a\u003e | \u003ca href=\"\/en-gb\/collections\/cat-pill-pockets\" title=\"Cat pill pockets \u0026amp; wraps: easy medication treats | hardypaw\" aria-label=\"Cat pill pockets \u0026amp; wraps: easy medication treats | hardypaw\"\u003eShop Pill Pockets for Cats\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eAdditional Information\u003c\/h3\u003e\n\u003ch4\u003ePrecautions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid With MAOIs:\u003c\/strong\u003e Pets currently receiving selegiline, amitraz, furazolidone, or isoniazid should not be given this medication due to the risk of serious MAOI-type interactions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid in Glaucoma:\u003c\/strong\u003e Pets with glaucoma should not receive this medication, as its anticholinergic properties can push intraocular pressure higher and make the condition worse.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid in Urinary Obstruction:\u003c\/strong\u003e Male cats with urinary obstruction and pets with gastrointestinal obstruction should not receive this medication, as anticholinergic effects can worsen both conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid in Pregnancy:\u003c\/strong\u003e Pregnant or lactating animals should not receive this medication without a veterinarian reviewing the risks and benefits beforehand.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCaution in Liver and Kidney Disease:\u003c\/strong\u003e Pets with liver or kidney impairment need careful management, as reduced organ function can significantly change how quickly the drug clears.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCaution in Heart Disease:\u003c\/strong\u003e Pets with heart failure, hyperthyroidism, or hypertension need extra care, as this medication can make these conditions worse.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Interaction Risk:\u003c\/strong\u003e Share a full list of your pet's current medications, particularly barbiturates, tranquilizers, and other CNS depressants, with your veterinarian before starting cyproheptadine.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePossible Side Effects\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrowsiness and Sedation:\u003c\/strong\u003e Mild sedation is the most commonly expected reaction in both dogs and cats and often settles with continued use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIncreased Appetite:\u003c\/strong\u003e Appetite stimulation is a recognized pharmacological effect of this medication and is used intentionally in cats and dogs with poor food intake.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDry Mouth and Constipation:\u003c\/strong\u003e Reduced salivation and slowed gut motility from the anticholinergic action of this medication are commonly seen in treated animals.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eParadoxical Excitability in Cats:\u003c\/strong\u003e Some cats respond with agitation, restlessness, and hyperexcitability instead of sedation, and this should be flagged to a veterinarian promptly.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSerious Allergic Reactions:\u003c\/strong\u003e Hives, facial swelling, or trouble breathing are rare but serious and need immediate emergency veterinary care.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eStorage Information\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoom Temperature:\u003c\/strong\u003e Tablets do best at room temperature inside a tightly closed container, kept away from heat and humidity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtect From Light and Moisture:\u003c\/strong\u003e Direct sunlight and damp conditions can chip away at the tablet's potency, so a dry, shaded storage spot is the right choice.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOut of Reach:\u003c\/strong\u003e Keep this medication somewhere children and untreated animals in the home cannot get to it.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cstrong\u003eNOTE: \u003c\/strong\u003e\u003c\/span\u003eFor generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.\u003c\/p\u003e\n\u003ch3\u003eShipping \u0026amp; Return\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, and priority delivery; see our \u003ca href=\"\/en-gb\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-gb\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eQ1: Why is cyproheptadine commonly prescribed as an appetite stimulant for cats?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e By blocking serotonin's appetite-suppressing influence in the central nervous system, cyproheptadine removes one of the key signals telling the cat not to eat. Cats dealing with chronic illness, post-operative recovery, or stress-related anorexia tend to respond well to it. It works best as part of a broader plan that also addresses what is causing the poor appetite rather than as the whole solution.\u003c\/p\u003e\n\u003ch3\u003eQ2: How does cyproheptadine act as an antidote for serotonin syndrome in pets?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e When serotonin builds up to dangerous levels in the nervous system, the result is tremors, seizures, hyperthermia, and a racing heart rate. Cyproheptadine gets ahead of that by taking hold of both peripheral and central serotonin receptors and cutting off the excess stimulation driving those reactions. It is brought into emergency management of serotonin toxicity from SSRIs, trazodone, tramadol, and similar drugs.\u003c\/p\u003e\n\u003ch3\u003eQ3: Why do some cats experience paradoxical excitability instead of sedation when taking cyproheptadine?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e First-generation antihistamines including cyproheptadine can trigger the opposite of what is expected in some cats, producing hyperactivity, agitation, and restlessness rather than calm. It tends to come up more at higher doses and is not predictable from one cat to the next. Unusual agitation after starting the medication is something a veterinarian should hear about, as a dose adjustment or a switch to something else may be the answer.\u003c\/p\u003e\n\u003ch3\u003eQ4: Can cyproheptadine be used for feline asthma in cats?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Cyproheptadine is used off-label in feline bronchial asthma because both histamine and serotonin play a role in the bronchoconstriction that drives the condition, and this medication takes on both. It usually sits alongside corticosteroids and bronchodilators rather than standing in for them. A veterinarian will assess whether it adds enough to the existing protocol to be worth including.\u003c\/p\u003e\n\u003ch3\u003eQ5: What distinguishes cyproheptadine from other antihistamines such as diphenhydramine or chlorpheniramine?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e What sets cyproheptadine apart is that it covers both histamine H1 receptors and serotonin receptors at the same time, giving it a wider pharmacological reach than antihistamines that only work on one receptor type. That serotonin-blocking side is what drives the appetite stimulation in cats and makes it useful in serotonin syndrome cases, two areas where diphenhydramine and chlorpheniramine simply do not have traction.\u003c\/p\u003e\n\u003ch2\u003eClinical Research\u003c\/h2\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.ajol.info\/index.php\/tjpr\/article\/view\/69540\" title=\"Https:\/\/www.ajol.info\/index.php\/tjpr\/article\/view\/69540\" aria-label=\"Visit a webpage about Https:\/\/www.ajol.info\/index.php\/tjpr\/article\/view\/69540\"\u003ehttps:\/\/www.ajol.info\/index.php\/tjpr\/article\/view\/69540\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022354915448270\" title=\"Https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/s0022354915448270\" aria-label=\"Visit a webpage about Https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/s0022354915448270\"\u003ehttps:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022354915448270\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Varies (Generic)","offers":[{"title":"1 tablet","offer_id":44412980953249,"sku":"389847-1","price":1.0,"currency_code":"GBP","in_stock":true},{"title":"30 tablets","offer_id":44412980986017,"sku":"389847-30","price":10.0,"currency_code":"GBP","in_stock":true},{"title":"60 tablets","offer_id":44412981018785,"sku":"389847-60","price":16.0,"currency_code":"GBP","in_stock":true},{"title":"100 tablets","offer_id":44412981084321,"sku":"389847","price":20.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/cyproheptadine-generic-tablets-antihistamine-for-dogs-cats-4-mg-457.png?v=1777915221","url":"https:\/\/hordypaw.shop\/en-gb\/products\/cyproheptadine-tablets-4mg","provider":"HardyPaw","version":"1.0","type":"link"}