Heartworm Preventives

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Sentinel Spectrum Chews for Dogs 8.1-25 lbs 6 chewables Sentinel Spectrum Chews for Dogs 8.1-25 lbs

Sentinel Spectrum Chews for Dogs 8.1-25 lbs

Merck Animal Health

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Advantage Multi 20.1-55 lbs, Red Advantage Multi 20.1-55 lbs, Red 1 month

Advantage Multi Topical Solution for Dogs 20.1-55 lbs, Red

Elanco

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Parasedge Multi for Dogs 9.1-20 lbsParasedge Multi for Dogs 9.1-20 lbs, (Teal Box) Parasedge Multi for Dogs 9.1-20 lbsParasedge Multi for Dogs 9.1-20 lbs 1 dose

Parasedge Multi for Dogs 9.1-20 lbs, (Teal Box)

Virbac

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Milbeguard for Dogs, 2-10 lb Milbeguard for Dogs, 2-10 lb 12 tablets

Milbeguard Flavored Tablets for Dogs, 2-10 lb

Ceva

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Immiticide Injection - Heartworm Treatment For Dogs 50mg 2mL (5 vials) - Pet Medicine 1

Immiticide Injection - Heartworm Treatment For Dogs 50mg, 2mL (5 vials)

Boehringer Ingelheim

$570.00
$456.00 Save 20% on 1st Autoship, 5% off future orders
Revolt Topical Solution for Cats 5.1-15 lbs Revolt Topical Solution for Cats 5.1-15 lbs backside

Revolt Topical Solution for Cats 5.1-15 lbs - Blue Box

Aurora Pharmaceutical

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Revolt Topical Solution for Dogs, 10.1-20 lbs Revolt Topical Solution for Dogs, 10.1-20 lbs backside

Revolt Topical Solution for Dogs, 10.1-20 lbs, (Brown Box)

Aurora Pharmaceutical

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Selarid for Puppies and Kittens 0-5 lbs Selarid for Puppies and Kittens 0-5 lbs Pet Medicine.

Selarid Topical Solution (Selamectin) for Puppies and Kittens 0-5 lbs

Varies (Generic)

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Revolution for Kittens & Puppies under 5 lbs 3 doses Revolution for Kittens & Puppies under 5 lbs

Revolution Topical Solution for Puppies, Kittens & Cats

Zoetis

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Iverhart Max Chew for Dogs 50.1-100 lbs 6 chewable Iverhart Max Chew for Dogs 50.1-100 lbs

Iverhart Max (Ivermectin & Pyrantel) Chews for Large Dogs 50.1-100 lbs

Virbac

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Advantage Multi for Cats, 9.1-18 lbs Advantage Multi for Cats, 9.1-18 lbs backside

Advantage Multi Topical Solution for Cats (Imidacloprid & Moxidectin), 9.1-18 lbs, Purple, 1 month

Elanco

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Trifexis for Dogs 60.1-120 lbs 6 chewable Trifexis for Dogs 60.1-120 lbs

Trifexis Chewable Tablets for Dogs 60.1-120 lbs (Spinosad + Milbemycin Oxime)

Elanco

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Trifexis for Dogs 10.1-20 lbs 6 chewable Trifexis for Dogs 10.1-20 lbs

Trifexis Chewable Tablets for Dogs 10.1-20 lbs (Spinosad + Milbemycin Oxime)

Elanco

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NexGard PLUS Chews for Small Dogs 4-8 lbs (Orange Box) - 6 Chews (6 month supply) - Pet Medication 1 NexGard PLUS Chews for Small Dogs 4-8 lbs (Orange Box) - Pet Medication 2

NexGard PLUS Chews for Small Dogs 4-8 lbs (Orange Box)

Boehringer Ingelheim

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Senergy Topical Solution for Cats, 5.1-15 lbs Senergy Topical Solution for Cats, 5.1-15 lbs 1 dose

Senergy Topical Solution for Cats, 5.1-15 lbs, (Blue Box)

Virbac

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Senergy Topical Solution for Dogs, 85.1-130 lbs Senergy Topical Solution for Dogs, 85.1-130 lbs 1 dose

Senergy Topical Solution for Extra Large Dogs, 85.1-130 lbs (Plum Box)

Virbac

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Milbeguard for Dog 26-50lb and Cats 6.1-12lb Milbeguard for Dog 26-50lb and Cats 6.1-12lb 12 tablets

Milbeguard for Dog 26-50lb and Cats 6.1-12lb

Ceva

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Selarid for Dogs 20.1-40 lbs Selarid for Dogs 20.1-40 lbs Pet Medicine.

Selarid Topical Solution for Dogs (20.1–40 lbs) – Red Box

Varies (Generic)

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Sentinel Spectrum Chews for Dogs 25.1-50 lbs 6 chewable Sentinel Spectrum Chews for Dogs 25.1-50 lbs

Sentinel Spectrum Chews for Dogs 25.1-50 lbs

Merck Animal Health

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Interceptor Plus Chew for Dogs - Pet Medicine 1 Interceptor Plus Chew for Dogs 8.1-25 lbs 5 diff worm

Interceptor Plus Chew for Dogs

Elanco

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Interceptor Chewable Tablets for Dogs & Cats - Pet Medicine 1 Interceptor Chewable Tablet for Dogs 51-100 lbs & Cats 12.1-25 lbs 6 chewable

Interceptor Chewable Tablets for Dogs & Cats

Novartis

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Iverhart Plus Chewable Tablet for Dogs 51-100 lbs 6 chewable Iverhart Plus Chewable Tablet for Dogs 51-100 lbs

Iverhart Plus Chewable Tablet for Large Dogs 51-100 lbs

Virbac

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Iverhart Max Chew for Dogs 6-12 lbs 6 chewable Iverhart Max Chew for Dogs 6-12 lbs

Iverhart Max (Ivermectin & Pyrantel) Chew for Toy Dogs 6-12 lbs

Virbac

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Trifexis for Dogs 20.1-40 lbs 6 chewable Trifexis for Dogs 20.1-40 lbs

Trifexis Chewble Tablets for Dogs (Spinosad + Milbemycin Oxime) 20.1-40 lbs

Elanco

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Safeguard Your Pets with The Best Heartworm Preventives

Heartworm disease is a life-threatening condition if not treated in time. It can damage your pet's heart, lungs, and circulatory system. Prevention is the only reliable defense. HardyPaw's collection includes trusted products like Heartgard Plus for dogs, Simparica Trio, and other prescription-strength medications that protect your pet at every stage of life.

Types of Heartworm Prevention

Different products fit different pets. This section outlines options to choose the safest, most effective solution for your pet's size and lifestyle.

Heartgard Plus

Heartgard Plus for dogs is one of the most popular preventives available.

  • Tasty monthly chew dogs love.
  • Prevents heartworm disease by killing larvae early.
  • Also controls roundworms and hookworms.
  • Available in sizes for small dogs up to large breeds (Heartgard Plus 51-100 lbs).

Heartgard for small dogs and puppies comes in lower-dose chewables.

Tri-Heart Plus

Tri Heart Plus for dogs offers the same active ingredients as Heartgard Plus.

  • Affordable monthly heartworm prevention for dogs.
  • Also treats and controls common intestinal parasites.
  • Easy-to-give chewable tablets.

Simparica Trio

Simparica Trio for dogs is a convenient all-in-one protection option.

  • Prevents heartworm disease by killing heartworm larvae before they mature, kills fleas and ticks, and treats intestinal parasites.
  • Monthly chewable available in different strengths, including Simparica Trio green for smaller dogs.
  • Great for families who want to simplify their pet's routine.

Other Prescription Heartworm Options

You can also find options that combine flea, tick, and heartworm prevention.

  • Flea, tick, and heartworm prevention for dogs.
  • Chews and tablets tailored by weight and age.
  • Prescription-only for reliable coverage.

How to Choose and Use Heartworm Preventives

Choosing the proper medication starts with a simple plan:

  • Talk to your vet to confirm your dog is heartworm-negative.
  • Choose a product based on weight, age, and lifestyle.
  • Give the chewable on the same day every month.
  • Use reminders or auto-ship to avoid missed doses.
  • Schedule annual heartworm tests to ensure continued protection.

Our team can help you compare products and dosing if you have questions.

Why Shop Heartworm Medications from HardyPaw?

Protecting your pet from a fatal disease requires trustworthy products. Here's how HardyPaw maintains that trust with its customers:

  • Vet-Recommended Brands: Choose trusted products like Heartgard Plus, Tri-Heart Plus, and Simparica Trio.
  • Licensed Pharmacy Fulfillment: Guaranteed authentic, safe medications for your pet.
  • Fast, Temperature-Controlled Shipping: Ensures products arrive fresh and effective.
  • Clear Dosing Guides: Easy-to-follow instructions with every order.
  • Friendly Expert Support: Help is always available to answer questions and guide you confidently.

Frequently Asked Questions

Q1: Which is the safest heartworm prevention for dogs?

Ans: The safest option depends on your dog's individual health, breed, weight, and lifestyle. Heartgard Plus and Simparica Trio are among the most widely recommended heartworm preventives by veterinarians. Always consult your vet before starting any preventive, as certain breeds such as Collies may have sensitivities to specific ingredients.

Q2: Can puppies take heartworm medicine?

Ans: Yes, but the minimum age varies by product. Heartgard Plus is approved for puppies 6 weeks and older, while Simparica Trio is approved for puppies 8 weeks and older weighing at least 2.8 lbs. Always consult your veterinarian to confirm which product is appropriate for your puppy's age and weight.

Q3: How often should I give heartworm medication?

Ans: Heartworm preventives are given once a month, year-round, even in winter. Mosquitoes, which transmit heartworm larvae, can remain active in warmer indoor environments during colder months. Consistent, uninterrupted monthly dosing is the only way to ensure your pet stays fully protected throughout the year.

Q4: Does Simparica Trio also prevent fleas and ticks?

Ans: Yes. Simparica Trio for dogs is an all-in-one chewable that protects against fleas, ticks, heartworms, and intestinal worms including roundworms and hookworms. It is a prescription-only monthly chewable that simplifies parasite prevention for pet owners managing multiple protection needs in a single dose.

Q5: Where can I buy heartworm prevention for dogs?

Ans: You can order Heartgard Plus, Tri-Heart Plus, Simparica Trio, and more products from HardyPaw with fast shipping. Simply upload your valid prescription at checkout and our team will verify it quickly. All medications are sourced from licensed suppliers to ensure authenticity and quality for your pet.

Q6: What happens if I miss a dose of heartworm prevention?

Ans: If you miss a dose, give it as soon as you remember and resume the monthly schedule from that date. Missing a dose can leave your pet unprotected and potentially allow heartworm larvae to mature. Contact your veterinarian if multiple doses have been missed, as a heartworm test may be recommended before restarting prevention.