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NexGard vs Advantage II: Finding the Best Flea Treatment for Dogs
Manan Chawla 12 min 19 sec read
Fleas and ticks are a problem almost every pet parent faces at some point. They can make your pet itchy, uncomfortable, and even sick if not treated quickly. A recent study by Merck Animal Health found that more than half of dog owners had to deal with fleas or ticks in the past year, showing how common these pests really are. (Source)
That’s why choosing the right flea and tick prevention for dogs is so important. Two of the most trusted flea control products for dogs are Advantage II and NexGard. Advantage II for dogs is a topical treatment that kills fleas on contact, while NexGard for dogs is a chewable that protects against both fleas and ticks.
In this blog, we’ll look at both products side by side so you can decide which one fits your pet’s lifestyle, comfort, and health needs best. The comparison between NexGard vs Advantage II will help you answer 'Which Monthly Flea & Tick Treatment for Dogs works better?'.
Getting to Know the Brands: Advantage II & NexGard
Advantage II (Elanco Animal Health)
Monthly over-the-counter topical treatment that kills fleas through contact and prevents re-infestation.
- Forms: Topical only (monthly)
- Duration: 4 weeks per application
- Active Ingredients: Imidacloprid and Pyriproxyfen
- Parasites Covered: Fleas (all stages), chewing lice (dogs only)
- Prescription: Not required (OTC product)
NexGard (Boehringer Ingelheim)
Monthly beef-flavored chewable for dogs that kills fleas and ticks systemically after they bite.
- Forms: Chewable tablet (dogs)
- Duration: 4 weeks per dose
- Active Ingredient: Afoxolaner
- Parasites Covered: Fleas and ticks (multiple species)
- Prescription: Required from your veterinarian
How Do NexGard and Advantage II Work?
About Advantage II (Bayer / Elanco)
Advantage II for dogs was first developed by Bayer Animal Health and is now part of Elanco. It is a popular topical flea treatment for dogs that starts working on contact, so fleas do not have to bite your pet to be affected. However, it’s important to note that Advantage II is not effective against ticks, as it is designed specifically to target and eliminate fleas.
How it works is Advantage II contains two ingredients: Imidacloprid and Pyriproxyfen. Imidacloprid acts on the flea’s central nervous system, causing paralysis and death; pyriproxyfen is an insect-growth regulator that prevents eggs/larvae from becoming adult fleas.(Source)
It kills fleas at every stage of life, including eggs, larvae, and adults, which helps prevent re-infestation. Advantage II is part of the trusted Advantage range that also includes Advantage Multi and Advantage for Cats.
Key point: Because Advantage II kills fleas before they bite, it can be a good option for pets with sensitive skin or flea allergies. Always follow Advantage II application instructions for best results.
About NexGard (Boehringer Ingelheim)
NexGard for dogs is made by Boehringer Ingelheim, a global leader in animal health. It is a chewable oral flea treatment for dogs that uses the active ingredient afoxolaner. This ingredient kills fleas and ticks after they bite your pet. NexGard is effective against several common tick species, including the Black-legged tick (Ixodes scapularis), American dog tick (Dermacentor variabilis), Brown dog tick (Rhipicephalus sanguineus), Lone star tick (Amblyomma americanum), and Asian longhorned tick (Haemaphysalis longicornis).
How it works: After ingestion, afoxolaner is absorbed and circulates in the bloodstream, when fleas/ticks bite the dog they ingest blood containing afoxolaner and the parasite is killed.
Many pet owners prefer NexGard chewables because they are easy to give, leave no mess, and come in a beef-flavored chew that dogs enjoy.
Key point: NexGard vs Advantage II comparisons often highlight that NexGard was the first FDA-approved chewable tablet that protects dogs from both fleas and ticks. Make sure to check proper NexGard dosage for dogs for safety.
Quick Comparison
| Feature | Advantage II | NexGard |
|---|---|---|
| Suitable Species | Dogs and cats (different formulas available) | Dogs only |
| Application Type | Topical (spot-on treatment applied to skin) | Oral chewable tablet (beef-flavored) |
| Protects Against | Fleas (adult, larvae, and eggs) and lice | Fleas and ticks (multiple tick species) |
| Starts Working In | About 12 hours after application | 4 to 8 hours after ingestion |
| Duration of Protection | 1 month | 1 month |
| Prescription Required | No – available over the counter | Yes – requires veterinary prescription |
| Safe for Puppies | 7 weeks and older | 8 weeks and older |
| Works After Bathing | Remains effective after 24–48 hours of application and bathing | Remains effective even after bathing or swimming |
| Active Ingredients | Imidacloprid, Pyriproxyfen | Afoxolaner |
| Best For | Pet parents preferring topical, non-prescription flea treatment for dogs or multi-pet homes (dogs & cats) | Pet parents seeking prescription flea and tick prevention for dogs in a convenient oral form |
How to Apply or Administer Each Treatment
Advantage II (Topical)
Apply directly to dry skin, not the fur, usually at the base of the neck.
- Part the fur and place the tube tip on the skin.
- Apply in one spot (small dogs) or 2–4 spots along the spine (large dogs).
- Make sure your dog is completely dry before applying, and keep them dry for 24 hours afterward.
- Keep pets from licking the area until it fully dries.
Note: Follow the exact instructions on the product label based on your dog’s weight.
NexGard (Oral Chew)
A monthly chew that works from inside the bloodstream.
- Give the correct dose based on weight.
- Offer as a treat or with food if needed.
- Make sure your dog consumes the full chew.
If your dog vomits within a couple of hours, consult your vet about re-dosing.
Important Safety Considerations
- NexGard should be given carefully to dogs that have a history of seizures.
- Advantage II should not be ingested and must be applied where your dog cannot lick easily.
- Always check age and weight eligibility before use.
- If you have multiple pets, keep them separated until the topical treatment dries.
Which Is Easier to Use?
- NexGard: More convenient for most owners, especially active or hard-to-handle dogs.
- Advantage II: Useful for dogs that refuse oral medication, but requires careful application.
Choosing the Right Product for Your Pet
Match your situation with the best option below. Clear problems and practical solutions make choosing easier.
Your pet hates taking pills
Solution: Apply Advantage II to the skin. It works on contact so fleas die before they bite.
- No pills or chews required
- Available without a prescription
- Kills fleas at every life stage
Note: Controls fleas and chewing lice. Does not protect against ticks.
You want a simple, mess free option
Solution: Give NexGard as a beef flavored chew. It remains effective after swimming or bathing.
- Protects against both fleas and ticks
- No residue and no waiting period
- Convenient monthly dosing
Important: NexGard is prescription only and should be used only on your veterinarian’s advice.
You want something affordable
Solution: Start with Advantage II for reliable flea control that is sold over the counter. Choose NexGard if you want broader protection in one chew and are comfortable getting a prescription.
You live in a tick heavy area
Solution: Choose NexGard for full tick coverage and fast kill. This helps lower the risk of tick borne illness.
You have a puppy or a sensitive pet
Solution: Follow age guidance. Advantage II is safe from 7 weeks of age. NexGard is approved from 8 weeks of age. Speak with your veterinarian before you start.
Quick takeaway
Pick Advantage II for affordable flea control without a prescription. Pick NexGard if you prefer a chewable that covers fleas and ticks. NexGard is a prescription product and should be used only on your veterinarian’s advice. Monthly use keeps your pet comfortable and protected.
Seasonality, Regional Risk, and Rotation Strategies
Flea and tick activity changes with the weather and your location. Understanding when and where these pests are most active can help you keep your pet protected all year long.
Understanding Seasonality
In many regions, fleas and ticks thrive in warm, humid weather, but that doesn’t mean your pet is safe in winter. Indoor heating and mild cold seasons can allow fleas to survive year-round. Even in cooler months, a quick walk through tall grass can expose pets to ticks. This is why most veterinarians recommend staying consistent with prevention every month of the year.
Regional Risk Levels
The risk of flea and tick exposure depends heavily on where you live. Use this quick guide to understand what to expect in your area:
| Region | Typical Risk Period | Recommended Focus |
|---|---|---|
| Warm & Humid (South, Coastal) | Year-round | Flea and tick protection all year (consider NexGard) |
| Moderate (Midwest, Central) | Spring to late fall | Monthly use during warm months (Advantage II or NexGard) |
| Cool & Dry (Northern States) | Spring through early fall | Focus on tick prevention (NexGard preferred) |
| Urban Areas | All year (indoor heating extends flea life) | Flea control for pets and environment (Advantage II) |
Rotation Strategies for Long-Term Protection
Some pet parents notice that a product seems less effective after long-term use. This can happen when local flea populations build resistance to certain ingredients. Rotating between approved flea and tick medications for dogs under veterinary guidance can help maintain effectiveness.
A simple rule to follow:
- Use one product consistently for several months to break the flea life cycle.
- Reevaluate every 6 to 12 months with your vet to see if a rotation or new product is needed.
- Always monitor your pet’s comfort and skin reactions when switching treatments.
The Takeaway
Flea and tick prevention for dogs is not just a summer task. It’s a year-round commitment to your pet’s comfort and health. By understanding your local risk and using a consistent or rotating prevention plan, you can keep your pet protected through every season.
Safety, Side Effects, and Vet Guidance
Advantage II Safety
Advantage II for dogs is safe for most pets when used correctly.
In rare cases, systemic effects have been reported in Advantage II, such as itching, vomiting, or depression. Monitor your pet after the first application.
Wait 24 to 48 hours after applying before bathing your pet to get the best results. Always follow Advantage II application instructions closely.
NexGard Safety
NexGard for dogs is also safe for most dogs. Some may experience mild side effects such as vomiting, diarrhea, or tiredness.
It should be used with care in dogs that have a history of seizures. Follow the recommended NexGard dosage for dogs to minimize risk.
Vet Advice
Always talk to your vet before starting or switching flea and tick prevention for dogs. Your vet can help you choose based on your pet’s:
- Health and medical history
- Daily routine and environment
- Exposure to fleas and ticks
Some products may not be suitable for pregnant, nursing, or breeding pets, so always read the label first.
Final Verdict: Which One Is Better?
| Category | Best Choice | Reason |
|---|---|---|
| Tick Protection | NexGard | Covers both fleas and ticks |
| Ease of Use | NexGard | Oral chewable with no mess |
| Flea Control | Both | Fast and effective |
| Puppy Safety | Advantage II | Safe from 7 weeks old |
| Budget-Friendly | Advantage II | Over the counter and affordable |
If you want complete flea and tick prevention for dogs and like the convenience of a chewable, NexGard for dogs is a great choice.
If you are mainly worried about fleas and want something simple and affordable, Advantage II for dogs is still one of the best options available.
Frequently Asked Questions
Q1. Can I use Advantage II and NexGard together?
Ans: It’s best not to use both unless your vet advises it. Combining flea and tick treatments can increase the risk of side effects. Your veterinarian can determine if your pet needs both or if one product alone offers sufficient protection.
Q2. Which one works faster?
Ans: Both products work quickly, but in slightly different ways. Advantage II begins killing fleas within about 12 hours of application, while NexGard starts working 4 to 12 hours after your dog eats the chew. Both provide fast, reliable protection when used correctly.
Q3. Are they safe for pregnant or nursing dogs?
Ans: Consult your veterinarian before using any flea and tick medication on breeding, pregnant, or nursing dogs. Advantage II is generally considered safe, but NexGard hasn’t been thoroughly tested for these conditions. Your vet can recommend the safest option for your dog’s needs.
Q4. What if my dog licks Advantage II?
Ans: If your dog licks the application site, they might drool, gag, or show mild nausea for a short time. These effects usually pass quickly, but you should call your vet if symptoms persist or your pet seems unusually uncomfortable afterward.
Q5. Can I switch between NexGard and Advantage II?
Ans: Yes, you can switch between them, but timing is important. Always ask your veterinarian first to avoid overlapping doses or gaps in protection. They can guide you on the best time to transition safely between treatments for your dog.
Q6. How do Advantage II and NexGard actually kill fleas and ticks?
Ans: Advantage II begins killing adult fleas on dogs in about 12 hours. It combines imidacloprid, which kills adult fleas on contact, with pyriproxyfen, an insect growth regulator that stops eggs and larvae from maturing, so fleas do not need to bite to die. Advantage II is also waterproof after 24 hours when applied correctly. Note that Advantage II only protects from fleas and not ticks.
NexGard is an oral chew, after your dog eats it the active ingredient afoxolaner circulates in the bloodstream and kills parasites after they bite. In lab studies NexGard began killing fleas within about 4 hours and showed more than 99 percent effectiveness by 8 hours. It also protects against several tick species that commonly affect dogs.
Q7: Is NexGard the best flea treatment?
Ans: Yes, NexGard is one of the most effective flea treatments for dogs, especially among oral options. It kills fleas quickly and provides monthly protection while also covering ticks.
- Type: Oral chewable
- Kills fleas after they bite
- Also protects against ticks
- Alternative: Advantage II is topical and flea-only
Q8: How long does NexGard take to work?
Ans: NexGard starts killing fleas within 4 hours and eliminates most fleas within 8–24 hours. It begins killing ticks within 24 hours, with full effectiveness typically within 48 hours.
- Fleas: starts in 4 hours
- Ticks: starts in 24 hours
- Full effect: 1–2 days
Q9: NexGard protects against how many tick species?
Ans: NexGard protects against at least 4 major tick species commonly found in dogs. These include American dog ticks, black-legged ticks, brown dog ticks, and lone star ticks.
- American dog tick
- Black-legged (deer) tick
- Brown dog tick
- Lone star tick
Q10: How effective is NexGard for fleas?
Ans: NexGard is highly effective against fleas, killing about 99% of fleas within 8 hours and preventing new infestations for up to 30 days.
- ~99% kill rate within 8 hours
- Stops fleas before they lay eggs
- Monthly protection per dose
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